SNRPB
| Gene Symbol | SNRPB |
|---|---|
| Entrez Gene | 6628 |
| Alt Symbol | CCMS, COD, SNRPB1, Sm-B/B', SmB/B', SmB/SmB', snRNP-B |
| Species | Human |
| Gene Type | protein-coding |
| Description | small nuclear ribonucleoprotein polypeptides B and B1 |
| Other Description | B polypeptide of Sm protein|Sm protein B/B'|sm-B/Sm-B'|small nuclear ribonucleoprotein polypeptide B|small nuclear ribonucleoprotein polypeptides B and B'|small nuclear ribonucleoprotein-associated proteins B and B' |
| Swissprots | Q9UIS5 Q15490 P14678 Q6IB35 |
| Accessions | AAD54488 AAD54489 CAA37170 CAA37171 CAH05601 EAX10596 EAX10597 EAX10598 EAX10599 P14678 AK301034 BAG62648 AK301206 BAG62782 AK307093 AK307266 AK312620 BAG35506 AY742712 AAU89981 BC003530 BC080516 AAH80516 BM559678 CR456969 CAG33250 HQ447543 ADQ32029 J04564 AAA60151 M34081 AAA36578 M34082 AAA36579 X15893 CAA33902 X17567 CAB57867 X17568 CAB57868 NM_003091 NP_003082 NM_198216 NP_937859 |
| Function | Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269|PubMed:18984161}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. |
| Top Pathways | Systemic lupus erythematosus, Spliceosome |
Sm B/B’ CRISPR/Cas9 KO Plasmid (h) - sc-404311 from Santa Cruz Biotechnology
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Sm B/B’ HDR Plasmid (h) - sc-404311-HDR from Santa Cruz Biotechnology
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Sm B/B’ Double Nickase Plasmid (h) - sc-404311-NIC from Santa Cruz Biotechnology
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Sm B/B’ Double Nickase Plasmid (h2) - sc-404311-NIC-2 from Santa Cruz Biotechnology
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Sm B/B’ CRISPR Activation Plasmid (h) - sc-404311-ACT from Santa Cruz Biotechnology
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Sm B/B’ CRISPR Activation Plasmid (h2) - sc-404311-ACT-2 from Santa Cruz Biotechnology
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Sm B/B’ Lentiviral Activation Particles (h) - sc-404311-LAC from Santa Cruz Biotechnology
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Sm B/B’ Lentiviral Activation Particles (h2) - sc-404311-LAC-2 from Santa Cruz Biotechnology
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Sm B/B' siRNA (h) - sc-36503 from Santa Cruz Biotechnology
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Sm B shRNA Plasmid (h) - sc-36503-SH from Santa Cruz Biotechnology
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Sm B shRNA (h) Lentiviral Particles - sc-36503-V from Santa Cruz Biotechnology
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SNRPB RNAi - H00006628-R01 from Novus Biologicals
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SNRPB RNAi - H00006628-R02 from Novus Biologicals
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MISSION® esiRNA - EHU159131 from Sigma-Aldrich
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MISSION® esiRNA - EHU146441 from Sigma-Aldrich
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MISSION® esiRNA - EHU125421 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20267 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20267 from Sigma-Aldrich
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SNRPB siRNA (Human) - CRH4511 from Cohesion Biosciences
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SNRPB - MBS8231391 from MyBioSource
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shRNA set against Human SNRPB (NM_003091.3) - SHH414328 from Creative biogene
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shRNA set against Human SNRPB(NM_003091.3) - SHL022130 from Creative biogene
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shRNA set against Human SNRPB(NM_198216.1) - SHL022169 from Creative biogene
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shRNA set against Human SNRPB(NM_003091.3) - SHL022246 from Creative biogene
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SNRPB shRNA Plasmid (Human) - CHH4511 from Cohesion Biosciences
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