| Gene Symbol |
SORBS3
|
| Entrez Gene |
10174
|
| Alt Symbol |
SCAM-1, SCAM1, SH3D4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sorbin and SH3 domain containing 3
|
| Other Description |
sorbin and SH3 domain-containing protein 3|vinexin|vinexin beta (SH3-containing adaptor molecule-1)
|
| Swissprots |
Q6NX54 Q5BJE4 Q96FY4 Q9UQE4 O60504
|
| Accessions |
EAW63673 EAW63674 EAW63675 EAW63676 O60504 AF037261 AAC09244 AF064807 AAD32304 AK301196 BAG62776 AK303950 BAG64877 BC004314 AAH04314 BC010146 AAH10146 BC067260 AAH67260 BC091514 AAH91514 BM999851 CF456833 CX783871 XM_005273371 XP_005273428 XM_006716266 XP_006716329 XM_006716268 XP_006716331 NM_001018003 NP_001018003 NM_005775 NP_005766
|
| Function |
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
|
| Subcellular Location |
Isoform Alpha: Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell- extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}.
|
| Tissue Specificity |
Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
|
![Western Blot: Vinexin Overexpression Lysate (Adult Normal) [NBP2-10442] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Vinexin.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2193_Vinexin%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10442-img0001.jpg)