Gene Symbol | SORBS3 |
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Entrez Gene | 10174 |
Alt Symbol | SCAM-1, SCAM1, SH3D4 |
Species | Human |
Gene Type | protein-coding |
Description | sorbin and SH3 domain containing 3 |
Other Description | sorbin and SH3 domain-containing protein 3|vinexin|vinexin beta (SH3-containing adaptor molecule-1) |
Swissprots | Q6NX54 Q5BJE4 Q96FY4 Q9UQE4 O60504 |
Accessions | EAW63673 EAW63674 EAW63675 EAW63676 O60504 AF037261 AAC09244 AF064807 AAD32304 AK301196 BAG62776 AK303950 BAG64877 BC004314 AAH04314 BC010146 AAH10146 BC067260 AAH67260 BC091514 AAH91514 BM999851 CF456833 CX783871 XM_005273371 XP_005273428 XM_006716266 XP_006716329 XM_006716268 XP_006716331 NM_001018003 NP_001018003 NM_005775 NP_005766 |
Function | Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain. |
Subcellular Location | Isoform Alpha: Cell junction {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized at cell- extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites. {ECO:0000250}. |
Tissue Specificity | Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver. |
Vinexin CRISPR/Cas9 KO Plasmid (h) - sc-405004 from Santa Cruz Biotechnology
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Vinexin HDR Plasmid (h) - sc-405004-HDR from Santa Cruz Biotechnology
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Vinexin Double Nickase Plasmid (h) - sc-405004-NIC from Santa Cruz Biotechnology
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Vinexin Double Nickase Plasmid (h2) - sc-405004-NIC-2 from Santa Cruz Biotechnology
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Vinexin CRISPR Activation Plasmid (h) - sc-405004-ACT from Santa Cruz Biotechnology
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Vinexin CRISPR Activation Plasmid (h2) - sc-405004-ACT-2 from Santa Cruz Biotechnology
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Vinexin Lentiviral Activation Particles (h) - sc-405004-LAC from Santa Cruz Biotechnology
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Vinexin Lentiviral Activation Particles (h2) - sc-405004-LAC-2 from Santa Cruz Biotechnology
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Vinexin siRNA (h) - sc-40342 from Santa Cruz Biotechnology
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Vinexin shRNA Plasmid (h) - sc-40342-SH from Santa Cruz Biotechnology
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Vinexin shRNA (h) Lentiviral Particles - sc-40342-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU018471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20335 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20335 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06491 from Sigma-Aldrich
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SORBS3 siRNA (Human) - CRH6871 from Cohesion Biosciences
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SORBS3 - MBS8232547 from MyBioSource
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shRNA set against Human SORBS3 (NM_005775.4) - SHH415128 from Creative biogene
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shRNA set against Human SORBS3(NM_005775.4) - SHL016650 from Creative biogene
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shRNA set against Human SORBS3(NM_001018003.2) - SHL016668 from Creative biogene
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Human SORBS3 siRNA - orb267373 from Biorbyt
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SORBS3 shRNA Plasmid (Human) - CHH6871 from Cohesion Biosciences
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SORBS3 miRNA 3'UTR clone - MiUTR1H-09751 from Creative biogene
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SORBS3 miRNA 3'UTR clone - MiUTR1H-09752 from Creative biogene
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