HCLS1

Gene Symbol HCLS1
Entrez Gene 3059
Alt Symbol CTTNL, HS1, lckBP1, p75
Species Human
Gene Type protein-coding
Description hematopoietic cell-specific Lyn substrate 1
Other Description hematopoietic lineage cell-specific protein
Swissprots B4DQ69 Q6IBK9 Q9UDK0 Q53Y93 P14317
Accessions EAW79505 EAW79506 P14317 AI091876 AK124015 AK225633 AK298663 BAG60831 AK298696 BAG60854 AK300301 BAG62054 AK312750 BAG35617 BC016758 AAH16758 BP338037 BQ002360 BT006824 AAP35470 BY994733 CA447092 CR456794 CAG33075 DC407066 DC427610 DQ890664 ABM81590 DQ893844 ABM84770 X16663 CAA34651 NM_001292041 NP_001278970 NM_005335 NP_005326
Function Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Subcellular Location Membrane {ECO:0000269|PubMed:7682714}; Peripheral membrane protein {ECO:0000269|PubMed:7682714}. Cytoplasm {ECO:0000269|PubMed:7682714}. Mitochondrion {ECO:0000305|PubMed:7682714}.
Tissue Specificity Expressed only in tissues and cells of hematopoietic origin.
Top Pathways Tight junction, Pathogenic Escherichia coli infection, Bacterial invasion of epithelial cells, Proteoglycans in cancer

Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb (PE Conjugate) - 11880 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D12C1
Flow cytometric analysis of Ramos cells, untreated (blue) or treated with anti-IgM and hydrogen peroxide (green), using Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb (PE Conjugate).

Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb (Alexa Fluor ® 647 Conjugate) - 13708 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D12C1
Immunofluorescent analysis of Ramos cells untreated (left) or treated with IgM (12 μg/mL, 10 min, right) using Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb (Alexa Fluor ® 647 Conjugate) (red). Blue pseudocolor= ProLong ® Gold Antifade Reagent with DAPI #8961.

Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) - 13090 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D12C1
Confocal immunofluorescent analysis of Ramos cells, serum starved (left) or treated with IgM (12 μg/mL for 10 min, right) using Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) (green). Red = Propidium Iodide (PI)/RNase Staining Solution #4087 (fluorescent DNA dye).

Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb (Pacific Blue™ Conjugate) - 13742 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Monoclonal
Clone D12C1
Flow cytometric analysis of Ramos cells, untreated (blue) or IgM-treated (green), using Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb (Pacific Blue™ Conjugate).

HS1 (D83A8) XP ® Rabbit mAb (Human Specific) (Alexa Fluor ® 647 Conjugate) - 12162 from Cell Signaling Technology

Prices $329.00
Sizes 100 µl (50 tests)
Host Rabbit
Clonality Polyclonal
Confocal immunofluorescent analysis of Jurkat (left) and 293 (right) cells using HS1 (D83A8) XP ® Rabbit mAb (Human Specific) (Alexa Fluor ® 647 Conjugate) (red). Blue pseudocolor = Propidium Iodide (PI)/RNase Staining Solution #4087.

Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb - 8714 from Cell Signaling Technology

Prices $119.00, $318.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D12C1
Western blot analysis of extracts from Ramos cells, serum starved for 12 hours, then treated with anti-IgM antibody or λ phosphatase, using Phospho-HS1 (Tyr397) (D12C1) XP ® Rabbit mAb (upper), or HS1 Antibody (Human Specific) #4503 (lower).

Phospho-HS1 (Tyr397) Antibody - 4507 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total extracts from Ramos cells, serum-starved for 2 hours and treated with anti-IgM antibody for 10 minutes, using Phospho-HS1 (Tyr397) Antibody (upper) or HS1 Antibody (Human Specific) #4503 (lower).

HS1 (D83A8) XP ® Rabbit mAb (Human Specific) - 3890 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D83A8
Western blot analysis of cell extracts from Raji, Jurkat, and Molt4 using HS1 (D83A8) XP ® Rabbit mAb (Human Specific).

HS1 (D5A9) XP ® Rabbit mAb (Rodent Specific) - 3892 from Cell Signaling Technology

Prices $277.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D5A9
Western blot analysis of cell extracts from Baf3, 32D, and mouse spleen using HS1 (D5A9) XP ® Rabbit mAb (Rodent Specific).

HS1 Antibody (Human Specific) - 4503 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell extracts from various cell types using HS1 Antibody (Human Specific).

Lck BP-1 (H-135) - sc-8328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Lck BP-1 (H-135): sc-8328. Western blot analysis of Lck BP-1 expression in Ramos (A), CCRF-CEM (B) and BJAB (C) whole cell lysates.

Lck BP-1 (C-17) - sc-1536 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Lck BP-1 (C-17): sc-1536. Western blot analysis of Lck BP-1 expression in Ramos (A) and CCRF-HSB-2 (B) whole cell lysates.

Lck BP-1 (N-18) - sc-1537 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Lck BP-1 (N-18): sc-1537. Western blot analysis of Lck BP-1 expression in CCRF-CEM (A), Jurkat (B), MOLT-4 (C) and HuT 78 (D) whole cell lysates.

Lck BP-1 (B-8) - sc-28382 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Lck BP-1 (B-8): sc-28382. Western blot analysis of Lck BP-1 expression in CCRF-CEM (A) and HuT 78 (B) whole cell lysates.

Lck BP-1 (9) - sc-135972 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Lck BP-1 (9): sc-135972. Western blot analysis of Lck BP-1 expression in human endothelial whole cell lysate.

Anti-HCLS1 antibody - ab116521 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-HCLS1 antibody (ab116521) at 1/100 dilution + MDA-MB231 cell line lysate at 35 µg

Anti-HCLS1 antibody - ab56039 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HCLS1 antibody [24] - ab106204 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 24
Anti-HCLS1 antibody [24] (ab106204) at 1/1000 dilution + Jurkat whole cell lysate

Anti-HCLS1 antibody - C-terminal - ab151511 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human gastric epithelium lymphocytes labeling HCLS1 with ab151511 at 1/100 dilution.

Anti-HCLS1 Antibody (phospho-Tyr397) - LS-C291213 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HCLS1 Antibody (aa350-400) - LS-C290243 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HCLS1 Antibody (aa300-350) - LS-C290241 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HCLS1 Antibody - LS-C310578 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-HCLS1 Antibody (phospho-Tyr397) - LS-C291584 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HCLS1 Antibody (aa361-391) - LS-C321897 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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