| Gene Symbol |
CREB3L2
|
| Entrez Gene |
64764
|
| Alt Symbol |
BBF2H7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cAMP responsive element binding protein 3-like 2
|
| Other Description |
B-ZIB transcription factor|BBF2 human homolog on chromosome 7|FUS/BBF2H7 protein|TCAG_1951439|basic transcription factor 2|cAMP-responsive element-binding protein 3-like protein 2|cyclic AMP-responsive element-binding protein 3-like protein 2
|
| Swissprots |
Q6ZMR6 Q6P454 Q70SY1
|
| Accessions |
EAL24050 EAW83878 EAW83879 EAW83880 Q70SY1 AJ549092 CAD79342 AJ549387 CAD79347 AK131517 BAD18659 AK293048 BAF85737 AL080209 BC015585 BC046181 AAH46181 BC063666 AAH63666 BC110813 AAI10814 BC131723 AAI31724 BQ711676 BX648300 BX649143 CN394705 CR749563 CAH18360 EU446520 ABZ92049 XM_005250541 XP_005250598 XM_011516492 XP_011514794 NM_001253775 NP_001240704 NM_194071 NP_919047
|
| Function |
Transcriptional activator which is processed and activated during endoplasmic reticulum stress late phase. Binds to the cAMP response element (CRE) and activates transcription through CRE. Regulates the transcription of unfolded protein response target genes, preventing accumulation of unfolded proteins in damaged neurons. Also regulates the expression of SEC23A, accelerating protein trafficking from the ER to the Golgi thereby playing a key role in chondrocyte differentiation and formation of epiphyseal cartilage (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:17178827}; Single-pass type II membrane protein {ECO:0000269|PubMed:17178827}.
|
| Tissue Specificity |
Widely expressed with highest levels in placenta, lung, spleen and intestine, and lowest levels in heart, brain, skeletal muscle, thymus, colon and leukocytes. In fetal tissues, the weakest expression is detected in brain and heart. {ECO:0000269|PubMed:12915480}.
|
| Top Pathways |
cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, PI3K-Akt signaling pathway
|
![Western Blot: CREB3L2 Overexpression Lysate (Adult Normal) [NBL1-09465] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CREB3L2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/700_CREB3L2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09465-img0002.jpg)