CBX8

Gene Symbol	CBX8
Entrez Gene	57332
Alt Symbol	PC3, RC1
Species	Human
Gene Type	protein-coding
Description	chromobox homolog 8
Other Description	Pc class 3 homolog\|chromobox homolog 8 (Pc class homolog, Drosophila)\|chromobox protein homolog 8\|polycomb 3\|rectachrome 1
Swissprots	Q9HC52 Q9NR07 Q96H39
Accessions	EAW89571 Q9HC52 AF174482 AAG09180 AF266479 AAF76328 AK074560 BAC11061 BC008937 AAH08937 BC009376 AAH09376 BC019289 AAH19289 EU446831 ABZ92360 NM_020649 NP_065700
Function	Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269\|PubMed:21282530}.
Subcellular Location	Nucleus {ECO:0000269\|PubMed:21282530}.

MPc3 (C-3) - sc-374332 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

MPc3 (C-3): sc-374332. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

MPc3 (A-20) - sc-23591 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MPc3 (A-20): sc-23591. Western blot analysis of MPc3 expression in K-562 (A) and SH-SY5Y (B) whole cell lysates.

MPc3 (F-20) - sc-19331 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

MPc3 (F-20): sc-19331. Western blot analysis of MPc3 expression in non-transfected: sc-117752 (A) and mouse MPc3 transfected: sc-125631 (B) 293T whole cell lysates.

Anti-Cbx8 antibody - ab182627 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin embedded Human lung cancer tissue labeling Cbx8 with ab182627 at 1/10 (left). The right shows the same analysis performed on tissue treated with the immunogen.

Anti-Cbx8 antibody - ab123657 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-Cbx8 antibody (ab123657) at 1/100 dilution + Mouse liver tissue lysate at 35 µg

Anti-CBX8 Antibody (clone 3D1) - LS-C175415 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	3D1

IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-CBX8 mouse monoclonal antibody.

Anti-CBX8 Antibody (aa374-409) - LS-C344464 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Western blot of lysate from mouse NIH/3T3 cell line with CBX8 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20 ug.

Anti-CBX8 Antibody (C-Terminus, clone 1214CT171.154.107) - LS-C344165 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Mouse
Clonality	Monoclonal
Clone	1214CT171.154.107

Western blot of lysates from 293, HeLa, A549 cell line (from left to right) with CBX8 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L (HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 35 ug per lane.

Anti-CBX8 Antibody (aa1-260, clone 4H3) - LS-C336987 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	4H3

IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-CBX8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-CBX8 Antibody (C-Terminus) - LS-C78021 from LifeSpan Bioscience

Prices	$545.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody - LS-C125268 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (aa178-191) - LS-C54621 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

Antibody (0.1 ug/ml) staining of K562 lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CBX8 Antibody (aa260-309) - LS-C29991 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (C-Terminus) - LS-C30927 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (aa71-120) - LS-C109939 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

CBX8 antibody LS-C109939 Western blot of COLO205 cell lysate.

Anti-CBX8 Antibody (aa161-189) - LS-C168368 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

CBX8 Antibody western blot of mouse liver tissue lysates (35 ug/lane). The CBX8 antibody detected the CBX8 protein (arrow).

Anti-CBX8 Antibody (aa160-189, AP) - LS-C233422 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (aa160-189, APC) - LS-C233424 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (aa160-189, Biotin) - LS-C233423 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (aa160-189, PE) - LS-C233430 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (aa160-189, FITC) - LS-C233425 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (clone 2A5) - LS-C175407 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2A5

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CBX8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CBX8.

Anti-CBX8 Antibody (C-Terminus, Biotin) - LS-C243895 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (C-Terminus, APC) - LS-C243893 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CBX8 Antibody (C-Terminus, AP) - LS-C243894 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

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