Gene Symbol | CBX8 |
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Entrez Gene | 57332 |
Alt Symbol | PC3, RC1 |
Species | Human |
Gene Type | protein-coding |
Description | chromobox homolog 8 |
Other Description | Pc class 3 homolog|chromobox homolog 8 (Pc class homolog, Drosophila)|chromobox protein homolog 8|polycomb 3|rectachrome 1 |
Swissprots | Q9HC52 Q9NR07 Q96H39 |
Accessions | EAW89571 Q9HC52 AF174482 AAG09180 AF266479 AAF76328 AK074560 BAC11061 BC008937 AAH08937 BC009376 AAH09376 BC019289 AAH19289 EU446831 ABZ92360 NM_020649 NP_065700 |
Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:21282530}. |
MPc3 CRISPR/Cas9 KO Plasmid (h) - sc-407903 from Santa Cruz Biotechnology
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MPc3 HDR Plasmid (h) - sc-407903-HDR from Santa Cruz Biotechnology
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MPc3 Double Nickase Plasmid (h) - sc-407903-NIC from Santa Cruz Biotechnology
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MPc3 Double Nickase Plasmid (h2) - sc-407903-NIC-2 from Santa Cruz Biotechnology
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MPc3 CRISPR Activation Plasmid (h) - sc-407903-ACT from Santa Cruz Biotechnology
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MPc3 CRISPR Activation Plasmid (h2) - sc-407903-ACT-2 from Santa Cruz Biotechnology
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MPc3 Lentiviral Activation Particles (h) - sc-407903-LAC from Santa Cruz Biotechnology
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MPc3 Lentiviral Activation Particles (h2) - sc-407903-LAC-2 from Santa Cruz Biotechnology
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MPc3 siRNA (h) - sc-38195 from Santa Cruz Biotechnology
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MPc3 shRNA Plasmid (h) - sc-38195-SH from Santa Cruz Biotechnology
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MPc3 shRNA (h) Lentiviral Particles - sc-38195-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU006711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5432 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5432 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01789 from Sigma-Aldrich
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CBX8 siRNA (Human) - CRJ1415 from Cohesion Biosciences
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CBX8 - MBS8222651 from MyBioSource
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shRNA set against Human CBX8 (NM_020649.2) - SHH255569 from Creative biogene
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CBX8 shRNA Plasmid (Human) - CHJ1415 from Cohesion Biosciences
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CBX8 miRNA 3'UTR clone - MiUTR4H-TG01666 from Creative biogene
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