Gene Symbol | CBX8 |
---|---|
Entrez Gene | 57332 |
Alt Symbol | PC3, RC1 |
Species | Human |
Gene Type | protein-coding |
Description | chromobox homolog 8 |
Other Description | Pc class 3 homolog|chromobox homolog 8 (Pc class homolog, Drosophila)|chromobox protein homolog 8|polycomb 3|rectachrome 1 |
Swissprots | Q9HC52 Q9NR07 Q96H39 |
Accessions | EAW89571 Q9HC52 AF174482 AAG09180 AF266479 AAF76328 AK074560 BAC11061 BC008937 AAH08937 BC009376 AAH09376 BC019289 AAH19289 EU446831 ABZ92360 NM_020649 NP_065700 |
Function | Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:21282530}. |