Gene Symbol |
CBX8
|
Entrez Gene |
57332
|
Alt Symbol |
PC3, RC1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
chromobox homolog 8
|
Other Description |
Pc class 3 homolog|chromobox homolog 8 (Pc class homolog, Drosophila)|chromobox protein homolog 8|polycomb 3|rectachrome 1
|
Swissprots |
Q9HC52 Q9NR07 Q96H39
|
Accessions |
EAW89571 Q9HC52 AF174482 AAG09180 AF266479 AAF76328 AK074560 BAC11061 BC008937 AAH08937 BC009376 AAH09376 BC019289 AAH19289 EU446831 ABZ92360 NM_020649 NP_065700
|
Function |
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. {ECO:0000269|PubMed:21282530}.
|
Subcellular Location |
Nucleus {ECO:0000269|PubMed:21282530}.
|