SBDS

Gene Symbol SBDS
Entrez Gene 51119
Alt Symbol CGI-97, SDS, SWDS
Species Human
Gene Type protein-coding
Description Shwachman-Bodian-Diamond syndrome
Other Description ribosome maturation protein SBDS
Swissprots Q9NV53 A8K0P4 Q9Y3A5 Q96FX0
Accessions CAG17753 EAX07906 Q9Y3A5 AF151855 AAD34092 AK001779 BAA91905 AK289609 BAF82298 AY169963 AAN77490 BC065700 AAH65700 HQ447454 ADQ31940 NM_016038 NP_057122
Function Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. {ECO:0000269|PubMed:17643419, ECO:0000269|PubMed:19602484, ECO:0000269|PubMed:19759903, ECO:0000269|PubMed:21536732}.
Subcellular Location Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903). {ECO:0000269|PubMed:19759903}.
Tissue Specificity Widely expressed.
Top Pathways Ribosome biogenesis in eukaryotes

SBDS (D-6) - sc-271600 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SBDS (D-6): sc-271600. Western blot analysis of SBDS expression in NIH/3T3 whole cell lysate.

SBDS (D-9) - sc-271350 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SBDS (D-9): sc-271350. Western blot analysis of SBDS expression in NIH/3T3 (A) and HeLa (B) whole cell lysates.

SBDS (FL-250) - sc-134735 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

SBDS (S-15) - sc-49257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SBDS (S-15): sc-49257. Western blot analysis of SBDS expression in non-transfected: sc-117752 (A) and human SBDS transfected: sc-117277 (B) 293T whole cell lysates.

Anti-Shwachman Bodian-Diamond syndrome antibody [AT1E8] - ab156615 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone AT1E8
Anti-Shwachman Bodian-Diamond syndrome antibody [AT1E8] (ab156615) at 1/3000 dilution + HeLa cell lysate at 40 µgSecondaryGoat anti-mouse HRPdeveloped using the ECL technique

Anti-Shwachman Bodian-Diamond syndrome antibody [EPR7819] - ab128905 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7819
All lanes : Anti-Shwachman Bodian-Diamond syndrome antibody [EPR7819] (ab128905) at 1/1000 dilutionLane 1 : 293T cell lysateLane 2 : CaCo 2 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat-anti-rabbit HRP at 1/2000 dilutiondeveloped using the ECL technique

Anti-Shwachman Bodian-Diamond syndrome antibody [EPR7820] - ab128946 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7820
All lanes : Anti-Shwachman Bodian-Diamond syndrome antibody [EPR7820] (ab128946) at 1/10000 dilutionLane 1 : 293T cell lysateLane 2 : HepG2 cell lysateLane 3 : Caco 2 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SBDS Antibody (Internal, clone EPR7819) - LS-C152557 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7819
Western blot analysis on (A) 293T and (B) Caco-2 cell lysates using anti-SBDS antibody.

Anti-SBDS Antibody (clone AT1E8) - LS-C175816 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone AT1E8
Western Blot: The cell lysates of HeLa (40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human SBDS antibody (1:3000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.

Anti-SBDS Antibody (C-Terminus, clone EPR7820) - LS-C152556 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7820
Western blot analysis on (A) 293T, (B) HepG2, and (C) Caco-2 cell lysates using anti-SBDS antibody.

Anti-SBDS Antibody - LS-C334358 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using SBDS antibody.

Anti-SBDS Antibody (C-Terminus) - LS-C40532 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SBDS antibody LS-C40532 Western blot of Jurkat lysate.

Anti-SBDS Antibody (aa51-100) - LS-C40531 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SBDS antibody LS-C40531 IHC of formalin-fixed, paraffin-embedded human Kidney. Positive label: Epithelial cells of renal tubule indicated with arrows. Antibody concentration 4-8 ug/ml. Magnification 400X.

Shwachman Bodian-Diamond syndrome Antibody - NBP1-32724 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Shwachman Bodian-Diamond syndrome Antibody [NBP1-32724] - Sample (30 ug of whole cell lysate)A: H1299B: HeLaC: Hep G2 12% SDS PAGE, antibody diluted at 1:1000.

Shwachman Bodian-Diamond syndrome Antibody - NBP1-55131 from Novus Biologicals

Prices $139.00, $299.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Shwachman Bodian-Diamond syndrome Antibody [NBP1-55131] - Titration: 2.5ug/ml Positive Control: Jurkat cell lysate.

Shwachman Bodian-Diamond syndrome Antibody - NBP1-87070 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Shwachman Bodian-Diamond syndrome Antibody [NBP1-87070] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue

Shwachman Bodian-Diamond syndrome Antibody (1E8) - NBP2-22594 from Novus Biologicals

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1E8
Western Blot: Shwachman Bodian-Diamond syndrome Antibody (1E8) [NBP2-22594] - Lane 1. 293T cell lysate, Lane 2. HeLa cell lysate.

Anti-SBDS (AB1) antibody produced in rabbit - AV45719 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SBDS (ab1): <B>Cat. No. AV45719</B>: Immunohistochemistry of SBDS in Human Kidney tissue with SBDS antibody at 4-8 μg/mL.

Anti-SBDS (96-110) antibody produced in rabbit - S2575 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-SBDS (96-110): <B>Cat. No. S2575</B>: Immunofluorescence of HUVEC cells using SBDS (96-110), Cat. No. S2575 (red) at a 1:100 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-SBDS antibody produced in rabbit - HPA028891 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SBDS: <B>Cat. No. HPA028891</B>: Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in glandular cells.

Anti-SBDS (136-150) antibody produced in rabbit - S2700 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-SBDS (136-150): <B>Cat. No. S2700</B>: Immunofluorescence of HUVEC cells using SBDS (136-150), Cat. No. S2700 (red) at a 1:50 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-SBDS (AB2) antibody produced in rabbit - AV45721 from Sigma-Aldrich

Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SBDS (ab2): <B>Cat. No. AV45721</B>: Immunohistochemistry of SBDS in Human Kidney tissue with SBDS antibody at 4-8 μg/mL.

SBDS antibody - N-terminal region (ARP45719_T100) - ARP45719_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SBDS antibody - C-terminal region (ARP45721_T100) - ARP45721_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SDS antibody - 10R-5712 from Fitzgerald

Prices $395.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3D3
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