SBDS

Gene Symbol	SBDS
Entrez Gene	51119
Alt Symbol	CGI-97, SDS, SWDS
Species	Human
Gene Type	protein-coding
Description	Shwachman-Bodian-Diamond syndrome
Other Description	ribosome maturation protein SBDS
Swissprots	Q9NV53 A8K0P4 Q9Y3A5 Q96FX0
Accessions	CAG17753 EAX07906 Q9Y3A5 AF151855 AAD34092 AK001779 BAA91905 AK289609 BAF82298 AY169963 AAN77490 BC065700 AAH65700 HQ447454 ADQ31940 NM_016038 NP_057122
Function	Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. {ECO:0000269|PubMed:17643419, ECO:0000269|PubMed:19602484, ECO:0000269|PubMed:19759903, ECO:0000269|PubMed:21536732}.
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903). {ECO:0000269|PubMed:19759903}.
Tissue Specificity	Widely expressed.
Top Pathways	Ribosome biogenesis in eukaryotes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SBDS - MBS1272726 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC065700

Human SBDS cDNA clone(NM_016038.2) - CDFG000031 from Creative Biomart Species Human Accession NM_016038.2

Human SBDS cDNA clone(NM_016038.2) - CDFG000035 from Creative Biomart Species Human Accession NM_016038.2

Human SBDS ORF Clone(NM_016038.2) - CDCR300390 from Creative Biomart Species Human Accession NM_016038.2

Human SBDS ORF Clone(NM_016038.2) - CDCR300391 from Creative Biomart Species Human Accession NM_016038.2

Human SBDS ORF Clone(NM_016038.2) - CDCR300392 from Creative Biomart Species Human Accession NM_016038.2

Human SBDS ORF Clone(NM_016038.2) - CDCL174588 from Creative Biomart Species Human Accession NM_016038.2

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone in cloning vector - HG15362-G from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, C-His tag - HG15362-CH from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, C-HA tag - HG15362-CY from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid - HG15362-UT from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15362-ANG from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15362-ACR from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15362-ANR from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15362-NF from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15362-ACG from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, N-HA tag - HG15362-NY from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, N-His tag - HG15362-NH from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15362-CF from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15362-NM from Sino Biological Species Human

Human SBDS / Shwachman-Bodian-Diamond syndrome Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15362-CM from Sino Biological Species Human

Human SBDS ORF Clone(NM_016038.2) - CDCR300390 from Creative biogene Species Human

Human SBDS ORF Clone (BC065700) - CDCS414138 from Creative biogene Species Human Accession Q9Y3A5

Human SBDS ORF clone (BC065700) - CDCB158235 from Creative biogene Species Human

Human SBDS cDNA Clone(NM_016038.2) - CDFG000031 from Creative biogene Species Human

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