SBDS

Gene Symbol	SBDS
Entrez Gene	51119
Alt Symbol	CGI-97, SDS, SWDS
Species	Human
Gene Type	protein-coding
Description	Shwachman-Bodian-Diamond syndrome
Other Description	ribosome maturation protein SBDS
Swissprots	Q9NV53 A8K0P4 Q9Y3A5 Q96FX0
Accessions	CAG17753 EAX07906 Q9Y3A5 AF151855 AAD34092 AK001779 BAA91905 AK289609 BAF82298 AY169963 AAN77490 BC065700 AAH65700 HQ447454 ADQ31940 NM_016038 NP_057122
Function	Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. {ECO:0000269|PubMed:17643419, ECO:0000269|PubMed:19602484, ECO:0000269|PubMed:19759903, ECO:0000269|PubMed:21536732}.
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903). {ECO:0000269|PubMed:19759903}.
Tissue Specificity	Widely expressed.
Top Pathways	Ribosome biogenesis in eukaryotes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Shwachman Bodian-Diamond syndrome full length protein - ab99957 from Abcam Category Protein Source E. coli Species Human

Human Shwachman Bodian-Diamond syndrome protein fragment - ab200496 from Abcam Category Protein Source E. coli Species Human

SBDS Antibody Blocking Peptide - LS-E16692 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SDS Antibody Blocking Peptide - LS-E9911 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SDS Antibody Blocking Peptide - LS-E15309 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Serine Dehydratase Protein - H00010993-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Shwachman Bodian-Diamond syndrome Protein - NBP1-49450 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Species Human

Shwachman Bodian-Diamond syndrome Recombinant Protein - P3412 from Novus Biologicals Category Protein Prices $549.00 Sizes 100 µg Species Human

SBDS Protein - GTX109168-pro from GeneTex Category Protein Prices $299.00 Sizes 25 μg Source E. coli Species Human

SBDS Protein (OPPA02486) - OPPA02486 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human SBDS protein (His Tag) - orb139626 from Biorbyt Category Protein Prices $323.00, $646.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Human SBDS protein - orb169250 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

SBDS Blocking Peptide - 33R-5342 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SBDS Blocking Peptide - 33R-2237 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SBDS protein (His tag) - 80R-1523 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

SDS Blocking Peptide - 33R-1011 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SDS Blocking Peptide - 33R-4446 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SBDS (1-250, His-tag) - AR09701PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

SBDS (1-250, His-tag) - AR09701PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

SBDS - P3412 from Acris Antibodies Category Protein Prices $500.00 Sizes 100 µg Species Human

Shwachman-Bodian-Diamond Syndrome, Human Recombinant - 228-13024-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Shwachman-Bodian-Diamond Syndrome Human - 228-13024-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Shwachman-Bodian-Diamond Syndrome Human - 228-13024-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

SBDS, 1-250aa, Human, His tag, E.coli - 01-2391 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

SBDS Recombinant Protein - 96-672 from ProSci Category Protein Prices $300.00 Sizes 100 µg Source E. coli Species Human

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