SBDS

Gene Symbol SBDS
Entrez Gene 51119
Alt Symbol CGI-97, SDS, SWDS
Species Human
Gene Type protein-coding
Description Shwachman-Bodian-Diamond syndrome
Other Description ribosome maturation protein SBDS
Swissprots Q9NV53 A8K0P4 Q9Y3A5 Q96FX0
Accessions CAG17753 EAX07906 Q9Y3A5 AF151855 AAD34092 AK001779 BAA91905 AK289609 BAF82298 AY169963 AAN77490 BC065700 AAH65700 HQ447454 ADQ31940 NM_016038 NP_057122
Function Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP- dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. {ECO:0000269|PubMed:17643419, ECO:0000269|PubMed:19602484, ECO:0000269|PubMed:19759903, ECO:0000269|PubMed:21536732}.
Subcellular Location Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle. Note=Primarily detected in the cytoplasm, and at low levels in nucleus and nucleolus (PubMed:19602484 and PubMed:17475909). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (PubMed:19759903). {ECO:0000269|PubMed:19759903}.
Tissue Specificity Widely expressed.
Top Pathways Ribosome biogenesis in eukaryotes

Ribosome matuion protein SBDS (SBDS), Human, ELISA Kit - E01R0426 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Ribosome matuion protein SBDS (SBDS), ELISA Kit - MBS7230057 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Ribosome matuion protein SBDS (SBDS), ELISA Kit - MBS7253405 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL

Ribosome matuion protein SBDS (SBDS), ELISA Kit - MBS7237281 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Shwachman-Bodian-Diamond syndrome, ELISA Kit - MBS9336139 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human SDS ELISA Kit - E034695 from Biobool

Category ELISA Kit

Human SBDS ELISA Kit - E035152 from Biobool

Category ELISA Kit

anti-SBDS antibody [1E8] - ARG57006 from Arigo Biolaboratories

Category ELISA Kit
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