RPS6KB2

Gene Symbol RPS6KB2
Entrez Gene 6199
Alt Symbol KLS, P70-beta, P70-beta-1, P70-beta-2, S6K-beta2, S6K2, SRK, STK14B, p70(S6K)-beta, p70S6Kb
Species Human
Gene Type protein-coding
Description ribosomal protein S6 kinase, 70kDa, polypeptide 2
Other Description 70 kDa ribosomal protein S6 kinase 2|P70S6K2|S6 kinase-related kinase|S6K-beta|S6K-beta-2|p70 S6 kinase beta|p70 S6K-beta|p70 S6KB|p70 ribosomal S6 kinase beta|p70-S6K 2|ribosomal protein S6 kinase beta-2|serine/threonine-protein kinase 14 beta|serine/threonine-protein kinase 14B
Swissprots B2RMZ9 Q9UEC1 B4DML8 O94809 Q9UBS0
Accessions EAW74618 EAW74619 EAW74620 EAW74621 Q9UBS0 AB016869 BAA34402 AB019245 BAA37145 AB208827 BAD92064 AF076931 AAD46063 AF099739 AAD20990 AK297527 BAG59930 BC000094 AAH00094 BC006106 AAH06106 BC136564 AAI36565 BX337895 BX538119 XM_005274164 XP_005274221 XM_005274165 XP_005274222 XM_006718655 XP_006718718 XM_006718656 XP_006718719 XM_006718657 XP_006718720 XR_247207 XR_247208 NM_003952 NP_003943 NM_001007071
Function Phosphorylates specifically ribosomal protein S6.
Subcellular Location Cytoplasm. Nucleus.
Top Pathways Fc gamma R-mediated phagocytosis, Proteoglycans in cancer, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway

p70 S6 Kinase 2 Antibody - 14130 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using p70 S6 Kinase 2 Antibody.

p70 S6 kinase β (C-19) - sc-9381 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p70 S6 kinase β (C-19): sc-9381. Immunofluorescence staining of methanol-fixed KNRK cells showing cytoplasmic localization.

p70 S6 kinase β (N-19) - sc-9379 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p70 S6 kinase β (N-19): sc-9379. Immunoperoxidase staining of formalin fixed, paraffin-embedded human bronchus tissue showing cytoplasmic staining of respiratory epithelial cells.

p70 S6 kinase β (O-21) - sc-130833 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
p70 S6 kinase β (O-21): sc-130833. Western blot analysis of p70 S6 kinase β expression in non-transfected (A) and human p70 S6 kinase β transfected (B) 293 whole cell lysates.

p-p70 S6 kinase α (A-6) - sc-8416 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Western blot analysis of p-p70 S6 kinase α activation in whole cell lysates from serum-starved (A,C) and serum-starved then serum-treated (B,D) NIH/3T3 cells. Antibodies tested include p-p70 S6 kinase α (H-9): sc-8418 (A,B) and p-p70 S6 kinase α (A-6): sc-8416 (C,D).

Anti-P70 S6 Kinase beta (phospho S371) antibody - ab60947 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab60947 at 1/50 - 1/100 dilution staining P70 S6 Kinase beta in human breast carcinoma by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.

Anti-P70 S6 Kinase beta (phospho S371) antibody [EPR2132] - ab109393 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2132
All lanes : Anti-P70 S6 Kinase beta (phospho S371) antibody [EPR2132] (ab109393) at 1/1000 dilutionLane 1 : 293T cell lysate, untreatedLane 2 : 293T cell lysate, treated with Alkaline Phosphatase (AP)Lysates/proteins at 10 µg per lane.

Anti-P70 S6 Kinase beta (phospho S423) antibody - ab138650 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-P70 S6 Kinase beta (phospho S423) antibody (ab138650) at 1/500 dilution + K562 cell extract (from cells treated with EGF at 200 ng/ml for 5 minutes) at 30 µg

Anti-P70 S6 Kinase beta (phospho T421 + S424) antibody - ab53029 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-P70 S6 Kinase beta (phospho T421 + S424) antibody (ab53029) at 1/500 dilutionLane 1 : NIH 3T3 cell extract treated with EGF (200ng/ml, 30mins) with immunising peptideLane 2 : NIH 3T3 cell extract treated with EGF (200ng/ml, 30mins)Observed band size : 79 kDa (why is the actual band size different from the predicted?)

Anti-P70 S6 Kinase beta antibody - ab131526 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-P70 S6 Kinase beta antibody (ab131526) at 1/500 dilutionLane 1 : 293 cell lysate with blocking peptideLane 2 : 293 cell lysate

Anti-P70 S6 Kinase beta antibody - ab196741 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-P70 S6 Kinase beta antibody (ab196741) at 1/500 dilutionLane 1 : 293 cell extractLane 2 : 293 cell extract with synthesized peptide

Anti-P70 S6 Kinase beta antibody - ab76960 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-P70 S6 Kinase beta antibody (ab76960) at 1/2500 dilution + Recombinant protein at 0.1 µg

Anti-P70 S6 Kinase beta antibody - ab70268 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC image of ab70268 staining in human breast carcinoma formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab70268, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-P70 S6 Kinase beta antibody - ab70271 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-P70 S6 Kinase beta antibody (ab70271) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 15 µgLane 2 : HeLa whole cell lysate at 5 µg

Anti-P70 S6 Kinase beta antibody - ab37699 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-P70 S6 Kinase beta antibody - ab52169 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical staining of human breast carcinoma tissue, using ab52169 (1/50 dilution), in the presence and absence of the immunising peptide. (Paraffin section).

Anti-P70 S6 Kinase beta antibody - ab70963 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-P70 S6 Kinase beta antibody (ab70963) at 1/50 dilutionLane 1 : 293 cell lysate, non transfected Lane 2 : 293 cell lysate transiently transfected with the P70 S6 Kinase beta gene Lysates/proteins at 2 µg per lane.

Anti-P70 S6 Kinase beta antibody - ab172306 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-P70 S6 Kinase beta antibody (ab172306) at 1 µg/mlLane 1 : Lysate from 293T cells transfected with P70 S6 kinase beta.Lane 2 : Lysate from untransfected 293T cells.Lysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-P70 S6 Kinase beta antibody [EPR14956] - N-terminal - ab184551 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14956
Flow cytometry analysis of 2% paraformaldehyde fixed HeLa cells labeling P70 S6 Kinase beta using ab184551 at a 1/100 dilution (red) or a Rabbit monoclonal IgG (green). Goat anti rabbit IgG (FITC) secondary at a 1/150 dilution

Anti-RPS6KB2 / S6K2 Antibody (aa300-350) - LS-C91204 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPS6KB2 / S6K2 Antibody (C-Terminus) - LS-C91205 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-RPS6KB1 / P70S6K / S6K Antibody (phospho-Thr389) - LS-C146919 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RPS6KB2 / S6K2 Antibody (aa2-410) - LS-C184865 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-RPS6KB2 / S6K2 Antibody (aa452-482) - LS-C99823 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-p70S6Kbeta antibody in A375 cell lysate. p70S6Kbeta (arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

Anti-RPS6KB2 / S6K2 Antibody (Ser417) - LS-C193119 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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