| Gene Symbol |
SCIN
|
| Entrez Gene |
85477
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
scinderin
|
| Other Description |
adseverin
|
| Swissprots |
A8K2U8 Q96PY2 Q96JC7 Q9Y6U3 Q8WU97 Q8NBZ6
|
| Accessions |
AAD15423 AAS07450 EAW93645 EAW93646 EAW93647 EAW93648 Q9Y6U3 AB067492 BAB67798 AF276507 AAK60494 AK027778 BAB55361 AK075123 BAC11416 AK075198 BAC11465 AK290363 BAF83052 BC021090 AAH21090 CA447429 CA448540 DB196860 DQ892033 ABM82959 DQ895224 ABM86150 XR_926951 NM_001112706 NP_001106177 NM_033128 NP_149119
|
| Function |
Ca(2+)-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis, Viral carcinogenesis, Regulation of actin cytoskeleton
|
![Western Blot: SCIN Overexpression Lysate (Adult Normal) [NBP2-04409] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SCIN.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8096_SCIN%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04409-img0001.jpg)