| Gene Symbol | NMRAL1 |
|---|---|
| Entrez Gene | 57407 |
| Alt Symbol | HSCARG, SDR48A1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NmrA-like family domain containing 1 |
| Other Description | nmrA-like family domain-containing protein 1|short chain dehydrogenase/reductase family 48A, member 1 |
| Swissprots | Q9HBL8 |
| Accessions | EAW85301 EAW85302 Q9HBL8 AF225419 AAG09721 AK098784 AW246763 BC002927 AAH02927 BC007364 AAH07364 HQ447357 ADQ31843 HY171572 XM_005255446 XP_005255503 XM_005255447 XP_005255504 XM_006720905 XP_006720968 XM_006720906 XP_006720969 XM_006725236 XP_006725299 XM_006725237 XP_006725300 XM_006725238 XP_006725301 XM_006725239 XP_006725302 XM_011522566 XP_011520868 XM_011522567 XP_011520869 XM_011546747 XP_011545049 XM_011546748 XP_011545050 NM_001305141 NP_001292070 NM_001305142 NP_001292071 NM_020677 NP_065728 |
| Function | Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. {ECO:0000269|PubMed:17496144, ECO:0000269|PubMed:18263583, ECO:0000269|PubMed:19254724}. |
| Subcellular Location | Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios. |