NMRAL1

Gene Symbol NMRAL1
Entrez Gene 57407
Alt Symbol HSCARG, SDR48A1
Species Human
Gene Type protein-coding
Description NmrA-like family domain containing 1
Other Description nmrA-like family domain-containing protein 1|short chain dehydrogenase/reductase family 48A, member 1
Swissprots Q9HBL8
Accessions EAW85301 EAW85302 Q9HBL8 AF225419 AAG09721 AK098784 AW246763 BC002927 AAH02927 BC007364 AAH07364 HQ447357 ADQ31843 HY171572 XM_005255446 XP_005255503 XM_005255447 XP_005255504 XM_006720905 XP_006720968 XM_006720906 XP_006720969 XM_006725236 XP_006725299 XM_006725237 XP_006725300 XM_006725238 XP_006725301 XM_006725239 XP_006725302 XM_011522566 XP_011520868 XM_011522567 XP_011520869 XM_011546747 XP_011545049 XM_011546748 XP_011545050 NM_001305141 NP_001292070 NM_001305142 NP_001292071 NM_020677 NP_065728
Function Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. {ECO:0000269|PubMed:17496144, ECO:0000269|PubMed:18263583, ECO:0000269|PubMed:19254724}.
Subcellular Location Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.

HSCARG (D-1) - sc-514369 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
HSCARG (D-1): sc-514369. Western blot analysis of HSCARG expression in HeLa (A) and A-375 (B) whole cell lysates.

HSCARG (Q-15) - sc-164609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
HSCARG (Q-15): sc-164609. Western blot analysis of HSCARG expression in Jurkat (A) and K-562 (B) whole cell lysates.

Anti-NMRAL1 antibody - ab86565 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-NMRAL1 antibody (ab86565) at 1 µg/ml (in 5% skim milk / PBS buffer) + Hela cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG should at 1/50000 dilution

Anti-NMRAL1 antibody - ab69203 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-NMRAL1 antibody (ab69203) at 1/500 dilutionLane 1 : NMRAL1 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

Anti-NMRAL1 / HSCARG Antibody (aa216-265) - LS-C102790 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NMRAL1 antibody LS-C102790 Western blot of HeLa lysate.

Anti-NMRAL1 / HSCARG Antibody (N-Terminus) - LS-C116087 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NMRAL1 antibody LS-C116087 Western blot of Mouse Heart lysate.

NMRAL1 Antibody - NBP1-83554 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NMRAL1 Antibody - NBP1-56439 from Novus Biologicals

Prices $369.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: NMRAL1 Antibody [NBP1-56439] - Hela cell lysate, concentration 0.2-1 ug/ml.

NMRAL1 Antibody - H00057407-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: NMRAL1 Antibody [H00057407-B01P] - Analysis of NMRAL1 expression in transfected 293T cell line by NMRAL1 polyclonal antibody. Lane 1: HSCARG transfected lysate(32.89 KDa). Lane 2: Non-transfected lysate.

Anti-NMRAL1 antibody produced in rabbit - SAB2101610 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NMRAL1: <B>Cat. No.SAB2101610</B>: NMRAL1 in HeLa cell lysate with NMRAL1 antibody at 1.0 μg/mL.

Anti-NMRAL1 antibody produced in mouse - SAB1407787 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NMRAL1: <B>Cat. No. SAB1407787</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~32.9 kDa using NMRAL1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-NMRAL1 (166-180) antibody produced in rabbit - SAB1102159 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human NMRAL1 was separated on SDS-PAGE, blotted with Anti-NMRAL1 (166-180) (<B>Cat. No. SAB1102159</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000 <BR/>2. Antibody dilution 1:1,000 + NMRAL1 immunizing peptide (human, 166-180)

Anti-NMRAL1 antibody produced in rabbit - HPA041353 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NMRAL1: <B>Cat. No. HPA041353</B>: Immunohistochemical staining of human rectum shows strong cytoplasmic and membranous positivity in glandular cells.

NMRAL1 antibody - middle region (ARP58502_P050) - ARP58502_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NMRAL1 antibody [N1C3] - GTX120363 from GeneTex

Host Rabbit
Clonality Polyclonal

NMRAL1 antibody, Internal - GTX44846 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

NMRAL1 antibody - 70R-18906 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

NMRAL1 antibody - 70R-3374 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

NMRAL1 antibody - 15765-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded human liver using 15765-1-AP(NMRAL1 antibody) at dilution of 1:50 (under 40x lens)

NMRAL1 antibody - H00057407-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot analysis of NMRAL1 expression in transfected 293T cell line (H00057407-T02) by NMRAL1 MaxPab polyclonal antibody. Lane 1: HSCARG transfected lysate(32.89 KDa). Lane 2: Non-transfected lysate.

NMRAL1 Antibody - 27-178 from ProSci

Prices $315.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Antibody used in WB on Human HeLa at 0.2-1 ug/ml.

NMRAL1 antibody - 15765-1-AP from Proteintech Group

Prices $279.00
Sizes con: 28 μg/150μl
Host Rabbit
Clonality Polyclonal
Jurkat cells were subjected to SDS PAGE followed by western blot with 15765-1-AP(NMRAL1 antibody) at dilution of 1:500

NMRAL1 Antibody - GWB-MV275E from Genway Biotech

Prices $368.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-NMRAL1 monoclonal antibody - DCABH-16213 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal

NmrA-like family domain containing 1 , Polyclonal Antibody - MBS714693 from MyBioSource

Prices $230.00, $500.00
Sizes 50 µl, 150 µl
Host Rabbit
Clonality Polyclonal
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