NMRAL1

Gene Symbol	NMRAL1
Entrez Gene	57407
Alt Symbol	HSCARG, SDR48A1
Species	Human
Gene Type	protein-coding
Description	NmrA-like family domain containing 1
Other Description	nmrA-like family domain-containing protein 1|short chain dehydrogenase/reductase family 48A, member 1
Swissprots	Q9HBL8
Accessions	EAW85301 EAW85302 Q9HBL8 AF225419 AAG09721 AK098784 AW246763 BC002927 AAH02927 BC007364 AAH07364 HQ447357 ADQ31843 HY171572 XM_005255446 XP_005255503 XM_005255447 XP_005255504 XM_006720905 XP_006720968 XM_006720906 XP_006720969 XM_006725236 XP_006725299 XM_006725237 XP_006725300 XM_006725238 XP_006725301 XM_006725239 XP_006725302 XM_011522566 XP_011520868 XM_011522567 XP_011520869 XM_011546747 XP_011545049 XM_011546748 XP_011545050 NM_001305141 NP_001292070 NM_001305142 NP_001292071 NM_020677 NP_065728
Function	Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. {ECO:0000269|PubMed:17496144, ECO:0000269|PubMed:18263583, ECO:0000269|PubMed:19254724}.
Subcellular Location	Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NMRAL1 full length protein - ab128450 from Abcam Category Protein Source E. coli Species Human

NMRAL1 / HSCARG Antibody Blocking Peptide - LS-E21404 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NMRAL1 / HSCARG Antibody Blocking Peptide - LS-E13389 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NMRAL1 Recombinant Protein - H00057407-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human NMRAL1 Protein - NBP1-98943 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Human NMRAL1 protein - orb168933 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

NMRAL1 Blocking Peptide - 33R-8999 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NMRAL1 protein (His tag) - 80R-2326 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

NMRAL1 (1-299, His-tag) - AR50410PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

NMRAL1 (1-299, His-tag) - AR50410PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

NMRAL1 - H00057407-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NMRAL1 - H00057407-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NMRAL1, 1-299 aa, Human, His tag, E.coli - 01-P1586 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NMRAL1 fusion protein - Ag8401 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NMRAL1 fusion protein - Ag8380 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

NMRAL1 Human - PRPS-1138 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

Recombinant Human NMRAL1 Protein - BP002931-PRO-1131 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

NMRAL1, 1-299 aa, Recombinant Protein - GWB-P0452J from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human NmrA-Like Family Domain Containing 1, His-tagged - NMRAL1-6837H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human NMRAL1, GST-tagged - NMRAL1-1317H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human NmrA-like family domain-containing protein 1(NMRAL1) - CSB-YP867194HU CSB-EP867194HU CSB-BP867194HU CSB-MP867194HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NMRAL1, 1-299aa, Human, His tag, E.coli - ATGP1586 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

NmrA-Like Family Domain Containing 1 Protein (Recombinant) - abx260904 from Abbexa Category Protein

NMRAL1 - TP303602 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NMRAL1 Recombinant Protein Antigen - NBP1-83554PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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