NMRAL1

Gene Symbol NMRAL1
Entrez Gene 57407
Alt Symbol HSCARG, SDR48A1
Species Human
Gene Type protein-coding
Description NmrA-like family domain containing 1
Other Description nmrA-like family domain-containing protein 1|short chain dehydrogenase/reductase family 48A, member 1
Swissprots Q9HBL8
Accessions EAW85301 EAW85302 Q9HBL8 AF225419 AAG09721 AK098784 AW246763 BC002927 AAH02927 BC007364 AAH07364 HQ447357 ADQ31843 HY171572 XM_005255446 XP_005255503 XM_005255447 XP_005255504 XM_006720905 XP_006720968 XM_006720906 XP_006720969 XM_006725236 XP_006725299 XM_006725237 XP_006725300 XM_006725238 XP_006725301 XM_006725239 XP_006725302 XM_011522566 XP_011520868 XM_011522567 XP_011520869 XM_011546747 XP_011545049 XM_011546748 XP_011545050 NM_001305141 NP_001292070 NM_001305142 NP_001292071 NM_020677 NP_065728
Function Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. {ECO:0000269|PubMed:17496144, ECO:0000269|PubMed:18263583, ECO:0000269|PubMed:19254724}.
Subcellular Location Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios.

HSCARG CRISPR/Cas9 KO Plasmid (h) - sc-412790 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSCARG HDR Plasmid (h) - sc-412790-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSCARG Double Nickase Plasmid (h) - sc-412790-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSCARG Double Nickase Plasmid (h2) - sc-412790-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSCARG CRISPR Activation Plasmid (h) - sc-412790-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSCARG CRISPR Activation Plasmid (h2) - sc-412790-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSCARG Lentiviral Activation Particles (h) - sc-412790-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSCARG Lentiviral Activation Particles (h2) - sc-412790-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HSCARG siRNA (h) - sc-93304 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSCARG shRNA Plasmid (h) - sc-93304-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HSCARG shRNA (h) Lentiviral Particles - sc-93304-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU144501 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15378 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15378 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NMRAL1 siRNA (Human) - CRJ1434 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NMRAL1 (NM_020677.3) - SHH353260 from Creative biogene

Category siRNA
Species Reactivities Human

NMRAL1 shRNA Plasmid (Human) - CHJ1434 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NMRAL1 miRNA 3'UTR clone - MiUTR3H-15594 from Creative biogene

Species Reactivities Human
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