RNF20

Gene Symbol	RNF20
Entrez Gene	56254
Alt Symbol	BRE1, BRE1A, hBRE1
Species	Human
Gene Type	protein-coding
Description	ring finger protein 20, E3 ubiquitin protein ligase
Other Description	BRE1 E3 ubiquitin ligase homolog|BRE1-A|E3 ubiquitin-protein ligase BRE1A|homolog of S. cerevisiae BRE1
Swissprots	Q9HA51 Q9NUR4 Q9H9Y7 Q8N3J4 Q5VTR2 Q6P527 Q96JD3 A7MCT5 Q9NX83 Q2TB34 Q69YL5 Q9NWQ3
Accessions	AAG24713 EAW58955 EAW58956 EAW58957 Q5VTR2 AF265230 AAK58539 AF283791 AAG44865 AF305515 AAG21410 AK000389 BAA91134 AK000697 BAA91326 AK002051 BAA92057 AK022300 BAB14005 AK022532 BAB14081 AK314401 BAG37025 AL832910 CAH10630 AL834272 CAD38947 AY006321 AAG15824 BC016691 AAH16691 BC032618 AAH32618 BC063115 AAH63115 BC110584 AAI10585 BC110585 AAI10586 BC152309 AAI52310 DB273543 XM_011518862 XP_011517164 NM_019592 NP_062538
Function	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19037095, ECO:0000305|PubMed:16337599}.
Tissue Specificity	Expressed in the normal brain and also in malignant gliomas (at protein level). {ECO:0000269|PubMed:19037095}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF20 Gene cDNA Clone - orb145089 from Biorbyt Prices $519.00 Sizes 10 μg Species Human

RNF20 - MBS1274394 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC110585

Human RNF20 cDNA clone(NM_019592.5) - CDFG002316 from Creative Biomart Species Human Accession NM_019592.5

Human RNF20 ORF Clone(NM_019592.5) - CDCL173851 from Creative Biomart Species Human Accession NM_019592.5

Human RNF20 ORF Clone(NM_019592.5) - CDCR304714 from Creative Biomart Species Human Accession NM_019592.5

Human RNF20 ORF Clone(NM_019592.5) - CDCR304715 from Creative Biomart Species Human Accession NM_019592.5

Mouse Rnf20 ORF Clone(NM_182999.2) - CDCL173852 from Creative Biomart

Human RNF20 Gene ORF cDNA clone in cloning vector - HG13962-G from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid - HG13962-UT from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, C-HA tag - HG13962-CY from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, N-His tag - HG13962-NH from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13962-NF from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, C-His tag - HG13962-CH from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13962-NM from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, N-HA tag - HG13962-NY from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13962-CF from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13962-CM from Sino Biological Species Human

Human RNF20 ORF Clone(NM_019592.5) - CDCR304714 from Creative biogene Species Human

Human RNF20 ORF Clone (BC110585) - CDCS414963 from Creative biogene Species Human Accession Q5VTR2

Human RNF20 ORF clone (BC110585) - CDCB159514 from Creative biogene Species Human

Human RNF20 cDNA Clone(NM_019592.5) - CDFG002316 from Creative biogene Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13962-ACR from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13962-ANR from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13962-ACG from Sino Biological Species Human

Human RNF20 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13962-ANG from Sino Biological Species Human

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