RNF20

Gene Symbol	RNF20
Entrez Gene	56254
Alt Symbol	BRE1, BRE1A, hBRE1
Species	Human
Gene Type	protein-coding
Description	ring finger protein 20, E3 ubiquitin protein ligase
Other Description	BRE1 E3 ubiquitin ligase homolog|BRE1-A|E3 ubiquitin-protein ligase BRE1A|homolog of S. cerevisiae BRE1
Swissprots	Q9HA51 Q9NUR4 Q9H9Y7 Q8N3J4 Q5VTR2 Q6P527 Q96JD3 A7MCT5 Q9NX83 Q2TB34 Q69YL5 Q9NWQ3
Accessions	AAG24713 EAW58955 EAW58956 EAW58957 Q5VTR2 AF265230 AAK58539 AF283791 AAG44865 AF305515 AAG21410 AK000389 BAA91134 AK000697 BAA91326 AK002051 BAA92057 AK022300 BAB14005 AK022532 BAB14081 AK314401 BAG37025 AL832910 CAH10630 AL834272 CAD38947 AY006321 AAG15824 BC016691 AAH16691 BC032618 AAH32618 BC063115 AAH63115 BC110584 AAI10585 BC110585 AAI10586 BC152309 AAI52310 DB273543 XM_011518862 XP_011517164 NM_019592 NP_062538
Function	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role inb histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of isoform 2 of PA2G4 in cancer cells leading to its proteasome-mediated degradation. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16337599, ECO:0000269|PubMed:19037095, ECO:0000269|PubMed:19410543}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:19037095, ECO:0000305|PubMed:16337599}.
Tissue Specificity	Expressed in the normal brain and also in malignant gliomas (at protein level). {ECO:0000269|PubMed:19037095}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF20 peptide - ab27758 from Abcam Category Peptide

Human RNF20 peptide - ab32628 from Abcam Category Peptide

Human RNF20 protein fragment - ab163369 from Abcam Category Protein Source Wheat germ Species Human

RNF20 Antibody Blocking Peptide - LS-E3057 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF20 Antibody Blocking Peptide - LS-E15921 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF20 Antibody Blocking Peptide - LS-E31441 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human RNF20 Protein - H00056254-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF20-Antibody-N-term-Blocking-Peptide - BP14192a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF20 Blocking Peptide - 33R-4353 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF20 Blocking Peptide - 33R-5103 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

BRE1A / RNF20 - H00056254-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BRE1A / RNF20 - H00056254-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF20 Peptide - 7357P from ProSci Category Peptide Species Human

RNF20 fusion protein - Ag16066 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RNF20 fusion protein - Ag17355 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

RNF20 Active Human Recombinant Protein - GWB-PSA6BC from Genway Biotech Category Protein Prices $485.00 Sizes 20 µg Species Human

Recombinant Human RNF20, GST-tagged - RNF20-2342H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase BRE1A(RNF20) ,partial - CSB-YP736198HU CSB-EP736198HU CSB-BP736198HU CSB-MP736198HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF20 Peptide, Human - M34GP13415H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNF20 Recombinant Protein Antigen - NBP2-54995PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

E3 ubiquitin-protein ligase BRE1A (RNF20), partial, Recombinant Protein - MBS1481874 from MyBioSource Category Protein Prices $835.00, $835.00, $1,055.00, $1,055.00, $1,170.00, $1,170.00, $1,620.00, $1,620.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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