| Gene Symbol | TAS2R4 |
|---|---|
| Entrez Gene | 50832 |
| Alt Symbol | T2R4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | taste receptor, type 2, member 4 |
| Other Description | candidate taste receptor T2R4|taste receptor type 2 member 4 |
| Swissprots | Q645W5 Q9NYW5 Q75MV8 |
| Accessions | AAF43904 AAS02039 BAD97921 BAD97922 BAD97923 CAC94173 CAC94265 CAC94358 CAC94451 CAI53523 EAL24016 EAW83983 Q9NYW5 BC130439 AAI30440 BC136508 AAI36509 HQ258372 ADR83126 NM_016944 NP_058640 |
| Function | Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. {ECO:0000269|PubMed:19628819}. |
| Subcellular Location | Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia. |
| Tissue Specificity | Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed on airway ciliated epithelium. {ECO:0000269|PubMed:19628819}. |
| Top Pathways | Taste transduction |
T2R4 (T-13) - sc-169494 from Santa Cruz Biotechnology
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T2R4 (Y-14) - sc-169495 from Santa Cruz Biotechnology
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Anti-TAS2R4 antibody - ab65489 from Abcam
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Anti-TAS2R4 antibody - ab80981 from Abcam
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Anti-TAS2R4 antibody - ab140425 from Abcam
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Anti-TAS2R4 / T2R4 Antibody (aa180-230) - LS-C95217 from LifeSpan Bioscience
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Anti-TAS2R4 / T2R4 Antibody (aa157-171) - LS-C155043 from LifeSpan Bioscience
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TAS2R4 Antibody - NB110-74890 from Novus Biologicals
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TAS2R4-aa157-171-Antibody-internal-region - AF3807a from Abgent, a WuXi AppTec company
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Goat anti-TAS2R4 (aa157-171) middle region Antibody (OAEB02997) - OAEB02997 from Aviva Systems Biology
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TAS2R4 antibody - H00050832-B01P from Acris Antibodies
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Anti-TAS2R4 Antibody - AC21-2706 from Abcore
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Anti-TAS2R4 Antibody (AMCA) - AC21-2706-01 from Abcore
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Anti-TAS2R4 Antibody (AP) - AC21-2706-02 from Abcore
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Anti-TAS2R4 Antibody (APC) - AC21-2706-03 from Abcore
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Anti-TAS2R4 Antibody (APC-Cy5.5) - AC21-2706-04 from Abcore
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Anti-TAS2R4 Antibody (APC-Cy7) - AC21-2706-05 from Abcore
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Anti-TAS2R4 Antibody (Avidin) - AC21-2706-06 from Abcore
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Anti-TAS2R4 Antibody (Biotin) - AC21-2706-07 from Abcore
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Anti-TAS2R4 Antibody (BPE) - AC21-2706-08 from Abcore
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Anti-TAS2R4 Antibody (Cy3) - AC21-2706-09 from Abcore
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Anti-TAS2R4 Antibody (Cy5) - AC21-2706-10 from Abcore
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Anti-TAS2R4 Antibody (Cy5.5) - AC21-2706-11 from Abcore
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Anti-TAS2R4 Antibody (FITC) - AC21-2706-12 from Abcore
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Anti-TAS2R4 Antibody (Glucose Oxidase) - AC21-2706-13 from Abcore
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