| Gene Symbol |
TAS2R4
|
| Entrez Gene |
50832
|
| Alt Symbol |
T2R4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
taste receptor, type 2, member 4
|
| Other Description |
candidate taste receptor T2R4|taste receptor type 2 member 4
|
| Swissprots |
Q645W5 Q9NYW5 Q75MV8
|
| Accessions |
AAF43904 AAS02039 BAD97921 BAD97922 BAD97923 CAC94173 CAC94265 CAC94358 CAC94451 CAI53523 EAL24016 EAW83983 Q9NYW5 BC130439 AAI30440 BC136508 AAI36509 HQ258372 ADR83126 NM_016944 NP_058640
|
| Function |
Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. {ECO:0000269|PubMed:19628819}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
|
| Tissue Specificity |
Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed on airway ciliated epithelium. {ECO:0000269|PubMed:19628819}.
|
| Top Pathways |
Taste transduction
|