Gene Symbol | TAS2R4 |
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Entrez Gene | 50832 |
Alt Symbol | T2R4 |
Species | Human |
Gene Type | protein-coding |
Description | taste receptor, type 2, member 4 |
Other Description | candidate taste receptor T2R4|taste receptor type 2 member 4 |
Swissprots | Q645W5 Q9NYW5 Q75MV8 |
Accessions | AAF43904 AAS02039 BAD97921 BAD97922 BAD97923 CAC94173 CAC94265 CAC94358 CAC94451 CAI53523 EAL24016 EAW83983 Q9NYW5 BC130439 AAI30440 BC136508 AAI36509 HQ258372 ADR83126 NM_016944 NP_058640 |
Function | Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. {ECO:0000269|PubMed:19628819}. |
Subcellular Location | Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia. |
Tissue Specificity | Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed on airway ciliated epithelium. {ECO:0000269|PubMed:19628819}. |
Top Pathways | Taste transduction |
TAS2R4 / T2R4 Antibody Blocking Peptide - LS-E27937 from LifeSpan Bioscience
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Recombinant Human TAS2R4 Protein - H00050832-G01-10ug from Novus Biologicals
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Goat anti TAS2R4 antibody Immunizing peptide - orb66412 from Biorbyt
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TAS2R4 Peptide - AC21-2706-P from Abcore
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TAS2R4 Peptide - 43-075P from ProSci
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TAS2R4, Peptide - MBS427787 from MyBioSource
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TAS2R4 Peptide, Human - M34GP15604H from Creative Peptides
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7100947 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7086181 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7086996 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7085743 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7085749 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7030987 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7030988 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7030990 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7030991 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7030992 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7030993 from MyBioSource
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Taste receptor type 2 member 4 (TAS2R4), Recombinant Protein - MBS7086588 from MyBioSource
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