TAS2R4

Gene Symbol TAS2R4
Entrez Gene 50832
Alt Symbol T2R4
Species Human
Gene Type protein-coding
Description taste receptor, type 2, member 4
Other Description candidate taste receptor T2R4|taste receptor type 2 member 4
Swissprots Q645W5 Q9NYW5 Q75MV8
Accessions AAF43904 AAS02039 BAD97921 BAD97922 BAD97923 CAC94173 CAC94265 CAC94358 CAC94451 CAI53523 EAL24016 EAW83983 Q9NYW5 BC130439 AAI30440 BC136508 AAI36509 HQ258372 ADR83126 NM_016944 NP_058640
Function Gustducin-coupled receptor for denatonium and N(6)- propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. {ECO:0000269|PubMed:19628819}.
Subcellular Location Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
Tissue Specificity Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. Expressed on airway ciliated epithelium. {ECO:0000269|PubMed:19628819}.
Top Pathways Taste transduction

T2R4 CRISPR/Cas9 KO Plasmid (h) - sc-417593 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

T2R4 HDR Plasmid (h) - sc-417593-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

T2R4 Double Nickase Plasmid (h) - sc-417593-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

T2R4 Double Nickase Plasmid (h2) - sc-417593-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

T2R4 CRISPR Activation Plasmid (h) - sc-417593-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

T2R4 CRISPR Activation Plasmid (h2) - sc-417593-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

T2R4 Lentiviral Activation Particles (h) - sc-417593-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

T2R4 Lentiviral Activation Particles (h2) - sc-417593-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

T2R4 siRNA (h) - sc-89642 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

T2R4 shRNA Plasmid (h) - sc-89642-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

T2R4 shRNA (h) Lentiviral Particles - sc-89642-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TAS2R4 RNAi - H00050832-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU019061 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21024 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21024 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TAS2R4 siRNA (Human) - CRH9413 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TAS2R4 - MBS8224363 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TAS2R4 (NM_016944.1) - SHH423544 from Creative biogene

Category siRNA
Species Reactivities Human

Human TAS2R4 siRNA - orb269915 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TAS2R4 shRNA Plasmid (Human) - CHH9413 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TAS2R4 miRNA 3'UTR clone - MiUTR1H-10197 from Creative biogene

Species Reactivities Human
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