| Gene Symbol |
APOBEC3D
|
| Entrez Gene |
140564
|
| Alt Symbol |
A3D, APOBEC3DE, APOBEC3E, ARP6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D
|
| Other Description |
DNA dC->dU-editing enzyme APOBEC-3D|apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3E pseudogene|probable DNA dC->dU-editing enzyme APOBEC-3D
|
| Swissprots |
Q96AK3 Q5JZ91 Q7Z2N6
|
| Accessions |
EAW60285 EAW60286 Q96AK3 BC017022 BC148619 AAI48620 BC153185 AAI53186 BE888971 BF832090 BM917407 BX340829 CR456396 CAG30282 CU012954 CAK54385 CU013242 CAK54684 DA287097 DB121958 EU527884 ACB32248 XM_005261337 XP_005261394 XM_006724139 XP_006724202 XM_011529892 XP_011528194 NM_152426 NP_689639
|
| Function |
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination- independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double- stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons. {ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:20062055, E
|
| Subcellular Location |
Cytoplasm. Cytoplasm, P-body.
|
| Tissue Specificity |
Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung. {ECO:0000269|PubMed:20308164}.
|