| Gene Symbol |
P2RX7
|
| Entrez Gene |
5027
|
| Alt Symbol |
P2X7
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
purinergic receptor P2X, ligand gated ion channel, 7
|
| Other Description |
ATP receptor|P2X purinoceptor 7|P2X7 receptor|P2Z receptor|purinergic receptor P2X, ligand-gated ion channel, 7|purinergic receptor P2X7 variant A
|
| Swissprots |
F5H6P2 E7EMK6 F8W951 Q4VKI1 Q4VKH9 O14991 A8K2Z0 Q4VKI3 Q96EV7 F5H7E8 Q4VKI0 Q99572 Q4VKH8 Q7Z771 Q4VKI4 Q4VKI2
|
| Accessions |
CAA73360 EAW98239 EAW98240 Q99572 AB209709 BAD92946 AK090866 BAG52241 AK225163 AK290405 BAF83094 AK294126 BAH11678 AK296432 BAH12350 AY847298 AAX82087 AY847299 AAX82088 AY847300 AAX82089 AY847301 AAX82090 AY847302 AAX82091 AY847303 AAX82092 AY847304 AAX82093 BC007679 AAH07679 BC011913 AAH11913 BC121157 AAI21158 BC121158 BI598073 DA274887 DA302256 DQ399293 ABD59798 DQ893457 ABM84383 DQ896337 ABM87336 GQ180122 ACS72266 JX471562 AFU91507 Y09561 CAA70755 XM_011538418 XP_011536720 XM_011538419 XP_011536721 XM_011538420 XP_011536722 NM_002562 NP_002553 NR_033948 NR_033949 NR_033950 NR_033951 NR_033952 NR_033953 NR_033954 NR_033955 NR_033956 NM_177427
|
| Function |
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12107182}; Multi-pass membrane protein.
|
| Tissue Specificity |
Widely expressed with highest levels in brain and immune tissues. {ECO:0000269|PubMed:15896293}.
|
| Top Pathways |
Calcium signaling pathway, Neuroactive ligand-receptor interaction
|