P2RX7

Gene Symbol P2RX7
Entrez Gene 5027
Alt Symbol P2X7
Species Human
Gene Type protein-coding
Description purinergic receptor P2X, ligand gated ion channel, 7
Other Description ATP receptor|P2X purinoceptor 7|P2X7 receptor|P2Z receptor|purinergic receptor P2X, ligand-gated ion channel, 7|purinergic receptor P2X7 variant A
Swissprots F5H6P2 E7EMK6 F8W951 Q4VKI1 Q4VKH9 O14991 A8K2Z0 Q4VKI3 Q96EV7 F5H7E8 Q4VKI0 Q99572 Q4VKH8 Q7Z771 Q4VKI4 Q4VKI2
Accessions CAA73360 EAW98239 EAW98240 Q99572 AB209709 BAD92946 AK090866 BAG52241 AK225163 AK290405 BAF83094 AK294126 BAH11678 AK296432 BAH12350 AY847298 AAX82087 AY847299 AAX82088 AY847300 AAX82089 AY847301 AAX82090 AY847302 AAX82091 AY847303 AAX82092 AY847304 AAX82093 BC007679 AAH07679 BC011913 AAH11913 BC121157 AAI21158 BC121158 BI598073 DA274887 DA302256 DQ399293 ABD59798 DQ893457 ABM84383 DQ896337 ABM87336 GQ180122 ACS72266 JX471562 AFU91507 Y09561 CAA70755 XM_011538418 XP_011536720 XM_011538419 XP_011536721 XM_011538420 XP_011536722 NM_002562 NP_002553 NR_033948 NR_033949 NR_033950 NR_033951 NR_033952 NR_033953 NR_033954 NR_033955 NR_033956 NM_177427
Function Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12107182}; Multi-pass membrane protein.
Tissue Specificity Widely expressed with highest levels in brain and immune tissues. {ECO:0000269|PubMed:15896293}.
Top Pathways Calcium signaling pathway, Neuroactive ligand-receptor interaction

P2X7 Receptor (E1E8T) Rabbit mAb - 13809 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone E1E8T
Western blot analysis of extracts from 293 cells, mock transfected (-) or transfected with a construct expressing Myc-tagged full-length human Myc-tagged P2X7 receptor protein (hP2X7-Myc; +), and UACC-62 cells, using P2X7 Receptor (E1E8T) Rabbit mAb.

P2X7 (H-265) - sc-25698 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
P2X7 (H-265): sc-25698. Immunofluorescence staining of methanol-fixed JAR cells showing cytoplasmic localization.

P2X7 (L-20) - sc-15200 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
P2X7 (L-20): sc-15200. Western blot analysis of P2X7 expression in rat pancreas tissue extract.

P2X7 (G-20) - sc-31500 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
P2X7 (G-20): sc-31500. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

P2X7 (Y-14) - sc-31499 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-P2RX7 antibody - ab77413 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab77413 stained HeLa cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab77413, used at a 1/100 dilution) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-P2RX7 antibody - ab93354 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
All lanes : Anti-P2RX7 antibody (ab93354) at 0.3 µg/mlLane 1 : Human brain frontal cortex lysateLane 2 : Human brain frontal cortex lysate with Immunising peptideLysates/proteins at 35 µg per lane.developed using the ECL technique

Anti-P2RX7 antibody - ab48871 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-P2RX7 antibody (ab48871) at 1.25 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilutiondeveloped using the ECL technique

Anti-P2RX7 antibody - ab94717 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-P2RX7 antibody (ab94717) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal stomach lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-P2RX7 antibody - ab140885 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of Formalin fixed and Paraffin Embedded Human pancreas nerve tissue labelling P2RX7 with ab140885 at 20 µg/ml.

Anti-P2RX7 antibody [EPR4723] - ab109246 from Abcam

Host Rabbit
Clonality Monoclonal
Clone EPR4723
Anti-P2RX7 antibody [EPR4723] (ab109246) at 1/160 dilution (unpurified) + Jurkat cell lysate at 20 µgSecondaryPeroxidase-conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Anti-P2RX7 / P2X7 Antibody (aa40-105) - LS-C136313 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-P2RX7 / P2X7 Antibody (clone HANO43, FITC) - LS-C185323 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone HANO43

Anti-P2RX7 / P2X7 Antibody (clone HANO43) - LS-C185322 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone HANO43

Anti-P2RX7 / P2X7 Antibody (clone Hano43, FITC) - LS-C188552 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone Hano43

Anti-P2RX7 / P2X7 Antibody (clone Hano43) - LS-C188553 from LifeSpan Bioscience

Prices $235.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone Hano43

Anti-P2RX7 / P2X7 Antibody (aa570-600, APC) - LS-C265388 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-P2RX7 / P2X7 Antibody (aa570-600, AP) - LS-C265389 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-P2RX7 / P2X7 Antibody (aa570-600, Biotin) - LS-C265391 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-P2RX7 / P2X7 Antibody (C-Terminus) - LS-C109995 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
P2RX7 / P2X7 antibody LS-C109995 Western blot of Fetal Stomach lysate.

Anti-P2RX7 / P2X7 Antibody (aa570-600, Azide-free, HRP) - LS-C265393 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-P2RX7 / P2X7 Antibody (aa570-600, FITC) - LS-C265392 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-P2RX7 / P2X7 Antibody (aa71-120) - LS-C115946 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
P2RX7 / P2X7 antibody LS-C115946 Western blot of Fetal Heart lysate.

Anti-P2RX7 / P2X7 Antibody (aa570-600, PE) - LS-C265394 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-P2RX7 / P2X7 Antibody (aa570-600) - LS-C323740 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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