| Gene Symbol |
SLC16A1
|
| Entrez Gene |
6566
|
| Alt Symbol |
HHF7, MCT, MCT1, MCT1D
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 16 (monocarboxylate transporter), member 1
|
| Other Description |
MCT 1|monocarboxylate transporter 1|solute carrier family 16 (monocarboxylic acid transporters), member 1|solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
|
| Swissprots |
Q49A45 Q5T8R6 P53985 Q9NSJ9
|
| Accessions |
CAD27707 EAW56551 EAW56552 EAW56553 P53985 AF239919 AI656300 AJ438942 AJ438943 AK000641 AK094064 AK296688 BAG59282 AK303603 BAG64618 AK312500 BAG35402 AL162079 CAB82412 BC026317 AAH26317 BC045664 AAH45664 BM712667 BP294493 DB443025 DQ895286 ABM86212 EU176206 ABW03657 EU831949 ACE87390 EU832043 ACE86705 L31801 AAC41707 XM_011542026 XP_011540328 XM_011542027 XP_011540329 XM_011548725 XP_011547027 XM_011548726 XP_011547028 NM_001166496 NP_001159968 NM_003051 NP_003042
|
| Function |
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. {ECO:0000269|PubMed:17701893}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:24390345}; Multi- pass membrane protein {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:24390345}.
|
| Tissue Specificity |
Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed. {ECO:0000269|PubMed:15505343}.
|