SLC16A1

Gene Symbol SLC16A1
Entrez Gene 6566
Alt Symbol HHF7, MCT, MCT1, MCT1D
Species Human
Gene Type protein-coding
Description solute carrier family 16 (monocarboxylate transporter), member 1
Other Description MCT 1|monocarboxylate transporter 1|solute carrier family 16 (monocarboxylic acid transporters), member 1|solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Swissprots Q49A45 Q5T8R6 P53985 Q9NSJ9
Accessions CAD27707 EAW56551 EAW56552 EAW56553 P53985 AF239919 AI656300 AJ438942 AJ438943 AK000641 AK094064 AK296688 BAG59282 AK303603 BAG64618 AK312500 BAG35402 AL162079 CAB82412 BC026317 AAH26317 BC045664 AAH45664 BM712667 BP294493 DB443025 DQ895286 ABM86212 EU176206 ABW03657 EU831949 ACE87390 EU832043 ACE86705 L31801 AAC41707 XM_011542026 XP_011540328 XM_011542027 XP_011540329 XM_011548725 XP_011547027 XM_011548726 XP_011547028 NM_001166496 NP_001159968 NM_003051 NP_003042
Function Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. {ECO:0000269|PubMed:17701893}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:24390345}; Multi- pass membrane protein {ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:24390345}.
Tissue Specificity Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed. {ECO:0000269|PubMed:15505343}.

MCT1 CRISPR/Cas9 KO Plasmid (h) - sc-400363 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCT1 HDR Plasmid (h) - sc-400363-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCT1 Double Nickase Plasmid (h) - sc-400363-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCT1 Double Nickase Plasmid (h2) - sc-400363-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCT1 CRISPR Activation Plasmid (h) - sc-400363-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCT1 CRISPR Activation Plasmid (h2) - sc-400363-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCT1 Lentiviral Activation Particles (h) - sc-400363-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCT1 Lentiviral Activation Particles (h2) - sc-400363-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCT1 siRNA (h) - sc-37235 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MCT1 shRNA Plasmid (h) - sc-37235-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MCT1 shRNA (h) Lentiviral Particles - sc-37235-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MCT1/SLC16A1 RNAi - H00006566-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU002571 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19422 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19422 from Sigma-Aldrich

Category ZFN Kit
Prices $4,120.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13213 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13213

SLC16A1 siRNA (Human) - CRH4455 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC16A1 - MBS8227095 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC16A1 (NM_003051.3) - SHH408552 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SLC16A1(NM_003051.3) - SHR229452 from Creative biogene

Category siRNA
Species Reactivities Human

MCT1 CRISPR/Cas9 KO Plasmid (h2) - sc-400363-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MCT1 HDR Plasmid (h2) - sc-400363-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Human SLC16A1 siRNA - orb264957 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC16A1 shRNA Plasmid (Human) - CHH4455 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC16A1 miRNA 3'UTR clone - MiUTR1H-09444 from Creative biogene

Species Reactivities Human
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