| Gene Symbol |
CRNN
|
| Entrez Gene |
49860
|
| Alt Symbol |
C1orf10, DRC1, PDRC1, SEP53
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cornulin
|
| Other Description |
53 kDa putative calcium-binding protein|53 kDa squamous epithelial-induced stress protein|58 kDa heat shock protein|squamous epithelial heat shock protein 53|tumor-related protein
|
| Swissprots |
Q8N613 B2RE60 Q9UBG3
|
| Accessions |
AAF00514 EAW53381 Q9UBG3 AF077831 AAD55747 AK291301 BAF83990 AK298640 BAG60815 AK316568 BAG38157 BC030807 AAH30807 DA420219 NM_016190 NP_057274
|
| Function |
Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. {ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16640557}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:16640557}. Note=Does not colocalize with TGM1.
|
| Tissue Specificity |
Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). {ECO:0000269|PubMed:11056050, ECO:0000269|PubMed:11606197, ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16466100, ECO:0000269|PubMed:16640557, ECO:0000269|PubMed:17289885}.
|