CRNN

Gene Symbol	CRNN
Entrez Gene	49860
Alt Symbol	C1orf10, DRC1, PDRC1, SEP53
Species	Human
Gene Type	protein-coding
Description	cornulin
Other Description	53 kDa putative calcium-binding protein|53 kDa squamous epithelial-induced stress protein|58 kDa heat shock protein|squamous epithelial heat shock protein 53|tumor-related protein
Swissprots	Q8N613 B2RE60 Q9UBG3
Accessions	AAF00514 EAW53381 Q9UBG3 AF077831 AAD55747 AK291301 BAF83990 AK298640 BAG60815 AK316568 BAG38157 BC030807 AAH30807 DA420219 NM_016190 NP_057274
Function	Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. {ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16640557}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:16640557}. Note=Does not colocalize with TGM1.
Tissue Specificity	Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). {ECO:0000269|PubMed:11056050, ECO:0000269|PubMed:11606197, ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16466100, ECO:0000269|PubMed:16640557, ECO:0000269|PubMed:17289885}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cornulin full length protein - ab93883 from Abcam Category Protein Source E. coli Species Human

CRNN / Cornulin Antibody Blocking Peptide - LS-E15632 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Cornulin Recombinant Protein - H00049860-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Cornulin Recombinant Protein - H00049860-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Cornulin Protein - NBP1-41224 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E. coli Species Human

CRNN Protein (OPPA02277) - OPPA02277 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human CRNN protein - orb81050 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Human Cornulin protein - orb49309 from Biorbyt Category Protein Prices $306.00, $680.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Cornulin Blocking Peptide - 33R-3210 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cornulin (1-495, His-tag) - AR09396PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

Cornulin (1-495, His-tag) - AR09396PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

Cornulin - H00049860-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cornulin - H00049860-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cornulin - H00049860-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Cornulin - H00049860-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cornulin - H00049860-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Cornulin, Human Recombinant - 228-13239-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Cornulin - 228-13239-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Cornulin - 228-13239-3 from RayBiotech Category Protein Prices $2,400.00 Sizes 3 µg Source Escherichia Coli. Species Human

Cornulin, Human, Recombinant - 19-C117 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source E. coli Species Human

CRNN, 1-495aa, Human, His tag, E.coli - 01-1794 from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Species Human

CRNN fusion protein - ag13372 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

CRNN fusion protein - Ag2374 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CRNN Human - PRPS-804 from NeoScientific Category Protein Prices $65.00, $169.00, $2,925.00 Sizes 5 µg, 25 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human CRNN Protein - BP001749-C117 from Syd Labs Category Protein Prices $126.00, $378.00, $2,640.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Human

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