CRNN
| Gene Symbol | CRNN |
|---|---|
| Entrez Gene | 49860 |
| Alt Symbol | C1orf10, DRC1, PDRC1, SEP53 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cornulin |
| Other Description | 53 kDa putative calcium-binding protein|53 kDa squamous epithelial-induced stress protein|58 kDa heat shock protein|squamous epithelial heat shock protein 53|tumor-related protein |
| Swissprots | Q8N613 B2RE60 Q9UBG3 |
| Accessions | AAF00514 EAW53381 Q9UBG3 AF077831 AAD55747 AK291301 BAF83990 AK298640 BAG60815 AK316568 BAG38157 BC030807 AAH30807 DA420219 NM_016190 NP_057274 |
| Function | Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. {ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16640557}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:16640557}. Note=Does not colocalize with TGM1. |
| Tissue Specificity | Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). {ECO:0000269|PubMed:11056050, ECO:0000269|PubMed:11606197, ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16466100, ECO:0000269|PubMed:16640557, ECO:0000269|PubMed:17289885}. |
cornulin CRISPR/Cas9 KO Plasmid (h) - sc-410525 from Santa Cruz Biotechnology
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cornulin HDR Plasmid (h) - sc-410525-HDR from Santa Cruz Biotechnology
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cornulin Double Nickase Plasmid (h) - sc-410525-NIC from Santa Cruz Biotechnology
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cornulin Double Nickase Plasmid (h2) - sc-410525-NIC-2 from Santa Cruz Biotechnology
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cornulin CRISPR Activation Plasmid (h) - sc-410525-ACT from Santa Cruz Biotechnology
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cornulin CRISPR Activation Plasmid (h2) - sc-410525-ACT-2 from Santa Cruz Biotechnology
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cornulin Lentiviral Activation Particles (h) - sc-410525-LAC from Santa Cruz Biotechnology
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cornulin Lentiviral Activation Particles (h2) - sc-410525-LAC-2 from Santa Cruz Biotechnology
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cornulin siRNA (h) - sc-88337 from Santa Cruz Biotechnology
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cornulin shRNA Plasmid (h) - sc-88337-SH from Santa Cruz Biotechnology
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cornulin shRNA (h) Lentiviral Particles - sc-88337-V from Santa Cruz Biotechnology
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Cornulin RNAi - H00049860-R01 from Novus Biologicals
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MISSION® esiRNA - EHU049801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6588 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6588 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02623 from Sigma-Aldrich
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CRNN siRNA (Human) - CRH9368 from Cohesion Biosciences
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CRNN - MBS8236069 from MyBioSource
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shRNA set against Human CRNN (NM_016190.2) - SHH269733 from Creative biogene
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Human CRNN siRNA - orb269870 from Biorbyt
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CRNN shRNA Plasmid (Human) - CHH9368 from Cohesion Biosciences
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CRNN miRNA 3'UTR clone - MiUTR4H-TG02360 from Creative biogene
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