CRNN

Gene Symbol CRNN
Entrez Gene 49860
Alt Symbol C1orf10, DRC1, PDRC1, SEP53
Species Human
Gene Type protein-coding
Description cornulin
Other Description 53 kDa putative calcium-binding protein|53 kDa squamous epithelial-induced stress protein|58 kDa heat shock protein|squamous epithelial heat shock protein 53|tumor-related protein
Swissprots Q8N613 B2RE60 Q9UBG3
Accessions AAF00514 EAW53381 Q9UBG3 AF077831 AAD55747 AK291301 BAF83990 AK298640 BAG60815 AK316568 BAG38157 BC030807 AAH30807 DA420219 NM_016190 NP_057274
Function Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest. {ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16640557}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:16640557}. Note=Does not colocalize with TGM1.
Tissue Specificity Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR). {ECO:0000269|PubMed:11056050, ECO:0000269|PubMed:11606197, ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:15896671, ECO:0000269|PubMed:16466100, ECO:0000269|PubMed:16640557, ECO:0000269|PubMed:17289885}.

cornulin (N-14) - sc-164097 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
cornulin (N-14): sc-164097. Western blot analysis of cornulin expression in non-transfected: sc-117752 (A) and mouse cornulin transfected: sc-178428 (B) 293T whole cell lysates.

Anti-Cornulin antibody - ab104675 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Cornulin antibody (ab104675) at 1 µg/ml + HT1080 cell lysate at 10 µg

Anti-CRNN / Cornulin Antibody (C-Terminus) - LS-C116211 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CRNN / Cornulin antibody LS-C116211 Western blot of HT1080 Cell lysate. Antibody concentration 1 ug/ml.

Anti-CRNN / Cornulin Antibody (aa199-229) - LS-C167053 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human skeletal muscle reacted with CRNN Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

Anti-CRNN / Cornulin Antibody (aa259-274) IHC-plus™ - LS-B626 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Anti-CRNN / Cornulin antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B626 concentration 5 ug/ml.

Cornulin Antibody - AF3607 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

Cornulin Antibody - NBP1-57075 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Cornulin Antibody [NBP1-57075] - HT1080 Whole Cell, concentration 1 ug/ml.

Cornulin Antibody - NBP1-88479 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: Cornulin Antibody [NBP1-88479] - Staining of human oral mucosa shows strong cytoplasmic positivity in squamous epithelial cells.

Cornulin Antibody - H00049860-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Cornulin Antibody [H00049860-B01] - analysis of CRNN expression in transfected 293T cell line by CRNN MaxPab polyclonal antibody. Lane 1: CRNN transfected lysate (54.45 KDa). Lane 2: Non-transfected lysate.

HSP58 Polyclonal Antibody - bs-5833R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CRNN antibody produced in rabbit - HPA024343 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-CRNN: <B>Cat. No. HPA024343</B>: Immunohistochemical staining of human oral mucosa shows strong cytoplasmic positivity in squamous epithelial cells.

Anti-CRNN antibody produced in rabbit - SAB2105465 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-CRNN: <B>Cat. No. SAB2105465</B>: CRNN in HT1080 cell lysates with CRNN antibody at 1.0 μg/mL.

CRNN antibody - middle region (ARP42460_P050) - ARP42460_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

CRNN antibody, Internal - GTX47019 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal
Anti-CRNN antibody, Internal used in Western blot. GTX47019

Human Cornulin Antibody - AF3607 from R&D Systems

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat

Human Cornulin Affinity Purified Polyclonal Ab, Goat IgG - AF3607-SP from R&D Systems

Host Goat
Clonality Polyclonal

CRNN antibody - 70R-16597 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti -Cornulin - C7901-10 from USBiological Life Science

Host Rabbit
Clonality Polyclonal

Cornulin antibody - 70R-4583 from Fitzgerald

Host Rabbit
Clonality Polyclonal

Cornulin Antibody - abx111803 from Abbexa

Host Rabbit
Clonality Polyclonal

Cornulin antibody - 11799-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded Cervical cancer using 11799-1-AP(CRNN Antibody) at Dilution 1:100 (under 10x lens)

Cornulin antibody - H00049860-B01 from Acris Antibodies

Prices $360.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot analysis of CRNN expression in transfected 293T cell line (H00049860-T01) by CRNN MaxPab polyclonal antibody.Lane 1: CRNN transf

Cornulin antibody - PAB13784 from Acris Antibodies

Prices $580.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunodetection of human CRNN using CRNN polyclonal antibody ( Cat # PAB13784 ) at 1 : 100 dilution. Staining performed on frozen sections of esophagus ( A, B ), foreskin ( C, D ) and scalp ( E, F ). Cornulin is expressed in the outer most layer of scalp skin and in the inner root sheat of the hair follicle, in normal esophagus, the staining is localized in the upper spinous and granular layers with strong peripheral localization. Control sections ( B, D, F ) show no staining.

Anti-Cornulin (SZ1229) - 23-10131 from ARP American Research Products

Prices $129.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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