RAPGEF6

Gene Symbol RAPGEF6
Entrez Gene 51735
Alt Symbol KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2
Species Human
Gene Type protein-coding
Description Rap guanine nucleotide exchange factor (GEF) 6
Other Description PDZ domain containing guanine nucleotide exchange factor (GEF) 2|PDZ domain-containing guanine nucleotide exchange factor 2|PDZ domain-containing guanine nucleotide exchange factor I|rap guanine nucleotide exchange factor 6
Swissprots Q8TEU7 Q8TEU6 A3KN82 E9PDV7 Q96PC1 Q8NI21 B7ZML2 A5PLL6
Accessions AAC04379 EAW62366 EAW62368 EAW62370 Q8TEU7 AF085846 AF394782 AAK83368 AF478468 AAL79915 AF478469 AAL79916 AF478567 AAM21637 AK056296 AK074318 BAB85049 AK302640 BAH13767 AL832899 AV726501 AW204176 BC133703 AAI33704 BC140820 AAI40821 BC142964 AAI42965 BC144627 AAI44628 BU568060 BX117281 BX649095 DA817493 NM_001164386 NP_001157858 NM_001164387 NP_001157859 NM_001164388 NP_001157860 NM_001164389 NP_001157861 NM_001164390 NP_001157862 NM_016340 NP_057424
Function Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11524421}. Cell membrane {ECO:0000269|PubMed:11524421}. Note=Upon binding to M-Ras, it translocates to the plasma membrane.
Tissue Specificity Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11524421}.
Top Pathways Rap1 signaling pathway

RAPGEF6 (F-8) - sc-398642 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RAPGEF6 (F-8): sc-398642. Western blot analysis of RAPGEF6 expression in HeLa nuclear extract (A) and T98G whole cell lysate (B).

RAPGEF6 (E-17) - sc-69596 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RAPGEF6 (E-17): sc-69596. Western blot analysis of RAPGEF6 expression in HeLa whole cell lysate.

RAPGEF6 (G-17) - sc-69597 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RAPGEF6 (G-17): sc-69597. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

RAPGEF6 (H-167) - sc-367562 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

RAPGEF6 (BA-17) - sc-81919 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
RAPGEF6 (BA-17): sc-81919. Western blot analysis of RAPGEF6 expression in HeLa nuclear extract.

Anti-RAGEF2 antibody - ab57221 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
RAGEF2 antibody (ab57221) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human pancreas.

Anti-RAGEF2 antibody - ab86225 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RAGEF2 antibody (ab86225) at 0.04 µgLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgdeveloped using the ECL technique

Anti-RAPGEF6 Antibody (aa86-135) - LS-C152109 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RAPGEF6 antibody Western Blot of Fetal Brain.

Anti-RAPGEF6 Antibody (clone 2C5) IHC-plus™ - LS-B6348 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2C5
Anti-RAPGEF6 / RAGEF2 antibody IHC of human tonsil, germinal center. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6348 concentration 5 ug/ml.

Anti-RAPGEF6 Antibody (aa1551-1601) - LS-C286222 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RAPGEF6 Antibody (aa625-675) - LS-C288729 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-RAPGEF6 Antibody (aa1012-1111, Azide-free) - LS-C328477 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

RAGEF2 Antibody (2C5) - H00051735-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C5

RAGEF2 Antibody - NBP1-87301 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: RAGEF2 Antibody [NBP1-87301] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli and cytoplasm.

RAGEF2 Antibody - NBP1-06551 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RAGEF2 Antibody [NBP1-06551] - Whole cell lysate from HeLa cells. PDZ-GEF2 was also immunoprecipitated by rabbit anti-PDZ-GEF2 antibody NBP1-06550.

RAGEF2 Antibody - NBP1-06550 from Novus Biologicals

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RAGEF2 Antibody [NBP1-06550] - Whole cell lysate from HeLa cells. PDZ-GEF2 was also immunoprecipitated by rabbit anti-PDZ-GEF2 antibody NBP1-06550.

RAGEF2 Antibody (2C5) - H00051735-M01A from Novus Biologicals

Prices $349.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone 2C5

RAGEF2 Polyclonal Antibody - bs-13698R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RAGEF2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13698R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RAGEF2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13698R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RAGEF2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13698R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RAGEF2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13698R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RAGEF2 Polyclonal Antibody, Cy3 Conjugated - bs-13698R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RAGEF2 Polyclonal Antibody, Cy5 Conjugated - bs-13698R-Cy5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RAGEF2 Polyclonal Antibody, Cy5.5 Conjugated - bs-13698R-Cy5.5 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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