RAPGEF6

Gene Symbol RAPGEF6
Entrez Gene 51735
Alt Symbol KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2
Species Human
Gene Type protein-coding
Description Rap guanine nucleotide exchange factor (GEF) 6
Other Description PDZ domain containing guanine nucleotide exchange factor (GEF) 2|PDZ domain-containing guanine nucleotide exchange factor 2|PDZ domain-containing guanine nucleotide exchange factor I|rap guanine nucleotide exchange factor 6
Swissprots Q8TEU7 Q8TEU6 A3KN82 E9PDV7 Q96PC1 Q8NI21 B7ZML2 A5PLL6
Accessions AAC04379 EAW62366 EAW62368 EAW62370 Q8TEU7 AF085846 AF394782 AAK83368 AF478468 AAL79915 AF478469 AAL79916 AF478567 AAM21637 AK056296 AK074318 BAB85049 AK302640 BAH13767 AL832899 AV726501 AW204176 BC133703 AAI33704 BC140820 AAI40821 BC142964 AAI42965 BC144627 AAI44628 BU568060 BX117281 BX649095 DA817493 NM_001164386 NP_001157858 NM_001164387 NP_001157859 NM_001164388 NP_001157860 NM_001164389 NP_001157861 NM_001164390 NP_001157862 NM_016340 NP_057424
Function Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11524421}. Cell membrane {ECO:0000269|PubMed:11524421}. Note=Upon binding to M-Ras, it translocates to the plasma membrane.
Tissue Specificity Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11524421}.
Top Pathways Rap1 signaling pathway

RAPGEF6 CRISPR/Cas9 KO Plasmid (h) - sc-403816 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAPGEF6 HDR Plasmid (h) - sc-403816-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAPGEF6 Double Nickase Plasmid (h) - sc-403816-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAPGEF6 Double Nickase Plasmid (h2) - sc-403816-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAPGEF6 CRISPR Activation Plasmid (h) - sc-403816-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAPGEF6 CRISPR Activation Plasmid (h2) - sc-403816-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAPGEF6 Lentiviral Activation Particles (h) - sc-403816-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAPGEF6 Lentiviral Activation Particles (h2) - sc-403816-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAPGEF6 siRNA (h) - sc-76349 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RAPGEF6 shRNA Plasmid (h) - sc-76349-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RAPGEF6 shRNA (h) Lentiviral Particles - sc-76349-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RAGEF2 RNAi - H00051735-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU092631 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17958 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17958 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09336 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09336

RAPGEF6 siRNA (Human) - CRH9925 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RAPGEF6 - MBS8239420 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RAPGEF6 CRISPR/Cas9 KO Plasmid (h2) - sc-403816-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RAPGEF6 HDR Plasmid (h2) - sc-403816-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human RAPGEF6 (NM_016340.5) - SHH389712 from Creative biogene

Category siRNA
Species Reactivities Human

Human RAPGEF6 siRNA - orb270427 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RAPGEF6 shRNA Plasmid (Human) - CHH9925 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RAPGEF6 miRNA 3'UTR clone - MiUTR3H-11268 from Creative biogene

Species Reactivities Human

RAPGEF6 miRNA 3'UTR clone - MiUTR3H-11269 from Creative biogene

Species Reactivities Human
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