| Gene Symbol | RAPGEF6 |
|---|---|
| Entrez Gene | 51735 |
| Alt Symbol | KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | Rap guanine nucleotide exchange factor (GEF) 6 |
| Other Description | PDZ domain containing guanine nucleotide exchange factor (GEF) 2|PDZ domain-containing guanine nucleotide exchange factor 2|PDZ domain-containing guanine nucleotide exchange factor I|rap guanine nucleotide exchange factor 6 |
| Swissprots | Q8TEU7 Q8TEU6 A3KN82 E9PDV7 Q96PC1 Q8NI21 B7ZML2 A5PLL6 |
| Accessions | AAC04379 EAW62366 EAW62368 EAW62370 Q8TEU7 AF085846 AF394782 AAK83368 AF478468 AAL79915 AF478469 AAL79916 AF478567 AAM21637 AK056296 AK074318 BAB85049 AK302640 BAH13767 AL832899 AV726501 AW204176 BC133703 AAI33704 BC140820 AAI40821 BC142964 AAI42965 BC144627 AAI44628 BU568060 BX117281 BX649095 DA817493 NM_001164386 NP_001157858 NM_001164387 NP_001157859 NM_001164388 NP_001157860 NM_001164389 NP_001157861 NM_001164390 NP_001157862 NM_016340 NP_057424 |
| Function | Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11524421}. Cell membrane {ECO:0000269|PubMed:11524421}. Note=Upon binding to M-Ras, it translocates to the plasma membrane. |
| Tissue Specificity | Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11524421}. |
| Top Pathways | Rap1 signaling pathway |