RAPGEF6

Gene Symbol	RAPGEF6
Entrez Gene	51735
Alt Symbol	KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2
Species	Human
Gene Type	protein-coding
Description	Rap guanine nucleotide exchange factor (GEF) 6
Other Description	PDZ domain containing guanine nucleotide exchange factor (GEF) 2|PDZ domain-containing guanine nucleotide exchange factor 2|PDZ domain-containing guanine nucleotide exchange factor I|rap guanine nucleotide exchange factor 6
Swissprots	Q8TEU7 Q8TEU6 A3KN82 E9PDV7 Q96PC1 Q8NI21 B7ZML2 A5PLL6
Accessions	AAC04379 EAW62366 EAW62368 EAW62370 Q8TEU7 AF085846 AF394782 AAK83368 AF478468 AAL79915 AF478469 AAL79916 AF478567 AAM21637 AK056296 AK074318 BAB85049 AK302640 BAH13767 AL832899 AV726501 AW204176 BC133703 AAI33704 BC140820 AAI40821 BC142964 AAI42965 BC144627 AAI44628 BU568060 BX117281 BX649095 DA817493 NM_001164386 NP_001157858 NM_001164387 NP_001157859 NM_001164388 NP_001157860 NM_001164389 NP_001157861 NM_001164390 NP_001157862 NM_016340 NP_057424
Function	Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP. {ECO:0000269|PubMed:11524421, ECO:0000269|PubMed:12581858}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11524421}. Cell membrane {ECO:0000269|PubMed:11524421}. Note=Upon binding to M-Ras, it translocates to the plasma membrane.
Tissue Specificity	Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:11524421}.
Top Pathways	Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RAGEF2 peptide - ab23175 from Abcam Category Peptide Species Human

Human RAGEF2 protein fragment - ab162655 from Abcam Category Protein Source Wheat germ Species Human

RAPGEF6 Antibody Blocking Peptide - LS-E23992 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RAGEF2 Protein - H00051735-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RAPGEF6 blocking peptide - GTX10000-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

RAPGEF6 - H00051735-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RAPGEF6 - H00051735-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDZ-GEF2 fusion protein - ag20325 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PDZ-GEF2 fusion protein - ag20340 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human RAPGEF6, GST-tagged - RAPGEF6-1632H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Rap guanine nucleotide exchange factor 6(RAPGEF6) ,partial - CSB-YP848419HU CSB-EP848419HU CSB-BP848419HU CSB-MP848419HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RAPGEF6 - TP317657 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RAGEF2 Recombinant Protein Antigen - NBP1-87301PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RAPGEF6 Peptide, Human - M34GP12972H from Creative Peptides Category Peptide Source Synthetic. Species Human

Rap guanine nucleotide exchange factor 6 (RAPGEF6), partial, Recombinant Protein - MBS1464499 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

RAGEF2 Recombinant Protein Antigen - NBP2-46660PEP from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µl Source E.coli Species Human

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