| Gene Symbol |
CREB3L3
|
| Entrez Gene |
84699
|
| Alt Symbol |
CREB-H, CREBH, HYST1481
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cAMP responsive element binding protein 3-like 3
|
| Other Description |
CREB/ATF family transcription factor|cyclic AMP-responsive element-binding protein 3-like protein 3
|
| Swissprots |
Q6ZMC5 B7ZL69 Q68CJ9 M0QYW7 B2R7S6 Q96TB9
|
| Accessions |
AAC34469 EAW69260 EAW69261 Q68CJ9 AB050902 BAB47242 AB073612 BAD38649 AK172839 BAD18804 AK313099 BAG35923 BC101504 AAI01505 BC101508 AAI01509 BC143609 AAI43610 BC143610 DA210258 EU446882 ABZ92411 NM_001271995 NP_001258924 NM_001271996 NP_001258925 NM_001271997 NP_001258926 NM_032607 NP_115996
|
| Function |
Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE (By similarity). Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. {ECO:0000250, ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215, ECO:0000269|PubMed:16469704}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:11353085}; Single-pass type II membrane protein {ECO:0000269|PubMed:11353085}.
|
| Tissue Specificity |
Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues. {ECO:0000269|PubMed:11353085, ECO:0000269|PubMed:15800215}.
|
| Top Pathways |
cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, PI3K-Akt signaling pathway
|