DBNL

Gene Symbol	DBNL
Entrez Gene	28988
Alt Symbol	ABP1, HIP-55, HIP55, SH3P7
Species	Human
Gene Type	protein-coding
Description	drebrin-like
Other Description	HPK1-interacting protein of 55 kDa|SH3 domain-containing protein 7|cervical SH3P7|cervical mucin-associated protein|drebrin-F|drebrin-like protein|src homology 3 domain-containing protein HIP-55
Swissprots	Q96K74 Q6IAI8 P84070 C9J7P1 Q9NR72 B4DDP6 Q9HBN8 Q96F30 Q9UJU6 A4D2I9 B4DEM2
Accessions	EAL23770 EAW61129 EAW61130 EAW61131 EAW61132 Q9UJU6 AB209486 BAD92723 AF077353 AAF80228 AF151364 AAG13120 AF197060 AAF13701 AF218020 AAG17262 AF250287 AAF81273 AK027367 BAB55065 AK126142 AK293151 BAG56697 AK293279 BAG56807 AK293340 BAG56856 AK293698 BAG57133 AK296778 BAG59356 AK298102 BAG60387 AK300630 BAG62321 AK302037 BAG63431 BC011677 AAH11677 BC023589 BC031687 AAH31687 CR457167 CAG33448 DC404852 HQ447892 ADQ32376 JF432143 ADZ15360 XM_011515325 XP_011513627 NM_001014436 NP_001014436 NM_001122956 NP_001116428 NM_001284313 NP_001271242 NM_001284315 NP_001271244 NM_014063 NP_054782
Function	Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}.
Subcellular Location	Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell projection {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HIP55 full length protein - ab131883 from Abcam Category Protein Source Wheat germ Species Human

Human HIP55 full length protein - ab131884 from Abcam Category Protein Source Wheat germ Species Human

Human HIP55 peptide - ab91635 from Abcam Category Peptide

AOC1 / ABP1 / DAO Antibody Blocking Peptide - LS-E2826 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

AOC1 / ABP1 / DAO Antibody Blocking Peptide - LS-E15427 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH3P7 / HIP-55 Antibody Blocking Peptide - LS-E4583 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH3P7 / HIP-55 Antibody Blocking Peptide - LS-E19596 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SH3P7 / HIP-55 Antibody Blocking Peptide - LS-E25356 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

HIP-55 Recombinant Protein - H00028988-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 25 ug 10 ug Species Human

ABP1/AOC1 Partial Recombinant Protein - H00000026-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human HIP-55 Protein - H00028988-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ABP1/AOC1 Protein - H00000026-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human ABP1/AOC1 Protein - H00000026-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

DBNL-Antibody-C-term-Blocking-Peptide - BP16932b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HIP55 blocking peptide - GTX89787-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

Goat anti DBNL antibody Immunizing peptide - orb17672 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

ABP1 Blocking Peptide - 33R-7547 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DBNL Blocking Peptide - 33R-7539 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

HIP55 Peptide - AC21-0184-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Drebrin-like protein (DBNL) - H00028988-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

Drebrin-like protein (DBNL) - H00028988-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Drebrin-like protein (DBNL) - H00028988-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Drebrin-like protein (DBNL) - H00028988-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

HIP-55 Peptide - 45-730P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

DBNL fusion protein - ag4078 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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