| Gene Symbol | DBNL |
|---|---|
| Entrez Gene | 28988 |
| Alt Symbol | ABP1, HIP-55, HIP55, SH3P7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | drebrin-like |
| Other Description | HPK1-interacting protein of 55 kDa|SH3 domain-containing protein 7|cervical SH3P7|cervical mucin-associated protein|drebrin-F|drebrin-like protein|src homology 3 domain-containing protein HIP-55 |
| Swissprots | Q96K74 Q6IAI8 P84070 C9J7P1 Q9NR72 B4DDP6 Q9HBN8 Q96F30 Q9UJU6 A4D2I9 B4DEM2 |
| Accessions | EAL23770 EAW61129 EAW61130 EAW61131 EAW61132 Q9UJU6 AB209486 BAD92723 AF077353 AAF80228 AF151364 AAG13120 AF197060 AAF13701 AF218020 AAG17262 AF250287 AAF81273 AK027367 BAB55065 AK126142 AK293151 BAG56697 AK293279 BAG56807 AK293340 BAG56856 AK293698 BAG57133 AK296778 BAG59356 AK298102 BAG60387 AK300630 BAG62321 AK302037 BAG63431 BC011677 AAH11677 BC023589 BC031687 AAH31687 CR457167 CAG33448 DC404852 HQ447892 ADQ32376 JF432143 ADZ15360 XM_011515325 XP_011513627 NM_001014436 NP_001014436 NM_001122956 NP_001116428 NM_001284313 NP_001271242 NM_001284315 NP_001271244 NM_014063 NP_054782 |
| Function | Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes. {ECO:0000250, ECO:0000269|PubMed:14729663}. |
| Subcellular Location | Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Cell projection {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity). {ECO:0000250}. |
HIP-55 CRISPR/Cas9 KO Plasmid (h) - sc-404008 from Santa Cruz Biotechnology
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HIP-55 HDR Plasmid (h) - sc-404008-HDR from Santa Cruz Biotechnology
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HIP-55 Double Nickase Plasmid (h) - sc-404008-NIC from Santa Cruz Biotechnology
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HIP-55 Double Nickase Plasmid (h2) - sc-404008-NIC-2 from Santa Cruz Biotechnology
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HIP-55 CRISPR Activation Plasmid (h) - sc-404008-ACT from Santa Cruz Biotechnology
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HIP-55 CRISPR Activation Plasmid (h2) - sc-404008-ACT-2 from Santa Cruz Biotechnology
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HIP-55 Lentiviral Activation Particles (h) - sc-404008-LAC from Santa Cruz Biotechnology
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HIP-55 Lentiviral Activation Particles (h2) - sc-404008-LAC-2 from Santa Cruz Biotechnology
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HIP-55 siRNA (h) - sc-75255 from Santa Cruz Biotechnology
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HIP-55 shRNA Plasmid (h) - sc-75255-SH from Santa Cruz Biotechnology
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HIP-55 shRNA (h) Lentiviral Particles - sc-75255-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU045501 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6951 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06622 from Sigma-Aldrich
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DBNL siRNA (Human) - CRH9151 from Cohesion Biosciences
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DBNL - MBS8239940 from MyBioSource
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shRNA set against Human DBNL (NM_014063.6) - SHH274781 from Creative biogene
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Human DBNL siRNA - orb269653 from Biorbyt
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DBNL shRNA Plasmid (Human) - CHH9151 from Cohesion Biosciences
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DBNL miRNA 3'UTR clone - MiUTR3H-11030 from Creative biogene
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DBNL miRNA 3'UTR clone - MiUTR3H-11031 from Creative biogene
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DBNL miRNA 3'UTR clone - MiUTR3H-11032 from Creative biogene
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