Fas

Gene Symbol Fas
Entrez Gene 14102
Alt Symbol AI196731, APO1, APT1, CD95, TNFR6, Tnfrsf6, lpr
Species Mouse
Gene Type protein-coding
Description Fas (TNF receptor superfamily member 6)
Other Description FASLG receptor|Fas (TNF receptor superfamily member)|Fas antigen|apo-1 antigen|apoptosis-mediating surface antigen FAS|lymphoproliferation|tumor necrosis factor receptor superfamily member 6
Swissprots Q9DCQ1 Q6GT31 P25446
Accessions AAB25700 AAG02410 AAK27371 AAY51770 AAY51771 AAY51772 AAY51773 AAY51774 CAC00638 EDL41748 P25446 AK002590 BAB22211 AK086933 BAC39766 BC061160 AAH61160 BY348234 DQ846748 ABI24112 DQ846749 ABI24113 L15352 L15353 L25336 M83649 AAA37593 XM_011247141 XP_011245443 NM_001146708 NP_001140180 NM_007987 NP_032013
Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death- inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS- mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Detected in various tissues including thymus, liver, lung, heart, and adult ovary.
Top Pathways Apoptosis, Proteoglycans in cancer, Non-alcoholic fatty liver disease (NAFLD), p53 signaling pathway, TNF signaling pathway

FAS CRISPR/Cas9 KO Plasmid (m) - sc-420287 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FAS HDR Plasmid (m) - sc-420287-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FAS Double Nickase Plasmid (m) - sc-420287-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FAS Double Nickase Plasmid (m2) - sc-420287-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FAS CRISPR Activation Plasmid (m) - sc-420287-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FAS CRISPR Activation Plasmid (m2) - sc-420287-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FAS Lentiviral Activation Particles (m) - sc-420287-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FAS Lentiviral Activation Particles (m2) - sc-420287-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

FAS siRNA (m) - sc-29312 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

FAS shRNA Plasmid (m) - sc-29312-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

FAS shRNA (m) Lentiviral Particles - sc-29312-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

MISSION® esiRNA - EMU031961 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN31184 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31184 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

FAS siRNA (Mouse) - CRM1308 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

FAS - MBS8212428 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse FAS (NM_007987.2) - SHH292477 from Creative biogene

Category siRNA
Species Reactivities Mouse

FAS shRNA Plasmid (Mouse) - CHM1308 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse
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