Gene Symbol | WASF1 |
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Entrez Gene | 8936 |
Alt Symbol | SCAR1, WAVE, WAVE1 |
Species | Human |
Gene Type | protein-coding |
Description | WAS protein family, member 1 |
Other Description | WASP family protein member 1|homology of dictyostelium scar 1|protein WAVE-1|verprolin homology domain-containing protein 1|wiskott-Aldrich syndrome protein family member 1 |
Swissprots | Q5SZK7 Q92558 E1P5F2 |
Accessions | CAC38904 CAC43533 EAW48325 EAW48326 EAW48327 EAW48328 EAW48329 EAW48330 Q92558 AF134303 AAD33052 AI928895 AK097838 BC044591 AAH44591 BC068546 BG719023 BI461486 D87459 BAA13399 XM_005267203 XP_005267260 XM_005267204 XP_005267261 XM_005267205 XP_005267262 XM_005267206 XP_005267263 XM_005267207 XP_005267264 XM_011536233 XP_011534535 XM_011536234 XP_011534536 XM_011536235 XP_011534537 NM_001024934 NP_001020105 NM_001024935 NP_001020106 NM_001024936 NP_001020107 NM_003931 NP_003922 |
Function | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. |
Subcellular Location | Cytoplasm, cytoskeleton. Cell junction, synapse {ECO:0000250}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas. |
Tissue Specificity | Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood. |
Top Pathways | Adherens junction, Fc gamma R-mediated phagocytosis, Bacterial invasion of epithelial cells, Salmonella infection, Choline metabolism in cancer |
Mouse/Human/Rat WASF1 / WAVE ELISA Kit (Cell-Based ELISA) - LS-F2388 from LifeSpan Bioscience
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Mouse/Human/Rat Phospho-WASF1 / WAVE (Tyr125) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1237 from LifeSpan Bioscience
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WAVE1 Colorimetric Cell-Based ELISA Kit - CB5728 from Assay Biotechnology
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WAVE1 (Phospho-Tyr125) Colorimetric Cell-Based ELISA Kit - CBP1232 from Assay Biotechnology
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WAS protein family, member 1, ELISA Kit - MBS9333005 from MyBioSource
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Wiskott-Aldrich syndrome protein family member 1, ELISA Kit - MBS282278 from MyBioSource
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WAVE1 ELISA Kit - DEIA-XYA1827 from Creative Diagnostics
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WAVE1 (Phospho-Tyr125) ELISA Kit - DEIA-XYA1828 from Creative Diagnostics
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Human WASF1 ELISA Kit - E040481 from Biobool
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WAVE1 Colorimetric Cell-Based ELISA Kit - EKA50625 from Biomatik
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