| Gene Symbol | WASF1 |
|---|---|
| Entrez Gene | 8936 |
| Alt Symbol | SCAR1, WAVE, WAVE1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | WAS protein family, member 1 |
| Other Description | WASP family protein member 1|homology of dictyostelium scar 1|protein WAVE-1|verprolin homology domain-containing protein 1|wiskott-Aldrich syndrome protein family member 1 |
| Swissprots | Q5SZK7 Q92558 E1P5F2 |
| Accessions | CAC38904 CAC43533 EAW48325 EAW48326 EAW48327 EAW48328 EAW48329 EAW48330 Q92558 AF134303 AAD33052 AI928895 AK097838 BC044591 AAH44591 BC068546 BG719023 BI461486 D87459 BAA13399 XM_005267203 XP_005267260 XM_005267204 XP_005267261 XM_005267205 XP_005267262 XM_005267206 XP_005267263 XM_005267207 XP_005267264 XM_011536233 XP_011534535 XM_011536234 XP_011534536 XM_011536235 XP_011534537 NM_001024934 NP_001020105 NM_001024935 NP_001020106 NM_001024936 NP_001020107 NM_003931 NP_003922 |
| Function | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. |
| Subcellular Location | Cytoplasm, cytoskeleton. Cell junction, synapse {ECO:0000250}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas. |
| Tissue Specificity | Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood. |
| Top Pathways | Adherens junction, Fc gamma R-mediated phagocytosis, Bacterial invasion of epithelial cells, Salmonella infection, Choline metabolism in cancer |
WAVE1 CRISPR/Cas9 KO Plasmid (h) - sc-401913 from Santa Cruz Biotechnology
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WAVE1 HDR Plasmid (h) - sc-401913-HDR from Santa Cruz Biotechnology
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WAVE1 Double Nickase Plasmid (h) - sc-401913-NIC from Santa Cruz Biotechnology
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WAVE1 Double Nickase Plasmid (h2) - sc-401913-NIC-2 from Santa Cruz Biotechnology
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WAVE1 CRISPR Activation Plasmid (h) - sc-401913-ACT from Santa Cruz Biotechnology
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WAVE1 CRISPR Activation Plasmid (h2) - sc-401913-ACT-2 from Santa Cruz Biotechnology
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WAVE1 Lentiviral Activation Particles (h) - sc-401913-LAC from Santa Cruz Biotechnology
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WAVE1 Lentiviral Activation Particles (h2) - sc-401913-LAC-2 from Santa Cruz Biotechnology
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WAVE1 siRNA (h) - sc-36831 from Santa Cruz Biotechnology
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WAVE1 shRNA Plasmid (h) - sc-36831-SH from Santa Cruz Biotechnology
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WAVE1 shRNA (h) Lentiviral Particles - sc-36831-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU145661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22776 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22776 from Sigma-Aldrich
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WASF1 siRNA (Human) - CRH5910 from Cohesion Biosciences
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WASF1 - MBS827811 from MyBioSource
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shRNA set against Human WASF1 (NM_003931.2) - SHH445600 from Creative biogene
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shRNA set against Human WASF1(NM_001024934.1) - SHL129648 from Creative biogene
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Human WASF1 siRNA - orb266412 from Biorbyt
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WASF1 shRNA Plasmid (Human) - CHH5910 from Cohesion Biosciences
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WASF1 miRNA 3'UTR clone - MiUTR1H-11186 from Creative biogene
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WASF1 miRNA 3'UTR clone - MiUTR3H-07307 from Creative biogene
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WASF1 miRNA 3'UTR clone - MiUTR3H-07308 from Creative biogene
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WASF1 miRNA 3'UTR clone - MiUTR3H-07309 from Creative biogene
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