Gene Symbol | WASF1 |
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Entrez Gene | 8936 |
Alt Symbol | SCAR1, WAVE, WAVE1 |
Species | Human |
Gene Type | protein-coding |
Description | WAS protein family, member 1 |
Other Description | WASP family protein member 1|homology of dictyostelium scar 1|protein WAVE-1|verprolin homology domain-containing protein 1|wiskott-Aldrich syndrome protein family member 1 |
Swissprots | Q5SZK7 Q92558 E1P5F2 |
Accessions | CAC38904 CAC43533 EAW48325 EAW48326 EAW48327 EAW48328 EAW48329 EAW48330 Q92558 AF134303 AAD33052 AI928895 AK097838 BC044591 AAH44591 BC068546 BG719023 BI461486 D87459 BAA13399 XM_005267203 XP_005267260 XM_005267204 XP_005267261 XM_005267205 XP_005267262 XM_005267206 XP_005267263 XM_005267207 XP_005267264 XM_011536233 XP_011534535 XM_011536234 XP_011534536 XM_011536235 XP_011534537 NM_001024934 NP_001020105 NM_001024935 NP_001020106 NM_001024936 NP_001020107 NM_003931 NP_003922 |
Function | Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. |
Subcellular Location | Cytoplasm, cytoskeleton. Cell junction, synapse {ECO:0000250}. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas. |
Tissue Specificity | Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood. |
Top Pathways | Adherens junction, Fc gamma R-mediated phagocytosis, Bacterial invasion of epithelial cells, Salmonella infection, Choline metabolism in cancer |
Human WAVE 1 protein fragment - ab152938 from Abcam
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WASF1 / WAVE Antibody Blocking Peptide - LS-E27245 from LifeSpan Bioscience
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Recombinant Human WASF1/WAVE1 Protein - H00008936-Q01 from Novus Biologicals
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WASF1-Antibody-Center-Blocking-peptide - BP14110c from Abgent, a WuXi AppTec company
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WAVE 1 Peptide - AC21-2823-P from Abcore
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WASF1 / WAVE1 - H00008936-Q01-10 from Acris Antibodies
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WASF1 / WAVE1 - H00008936-Q01-25 from Acris Antibodies
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WAVE1 (I119) Peptide - BS1608P from Bioworld Technology
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p-WAVE1 (Y125) Peptide - BS4370P from Bioworld Technology
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Recombinant Human Wiskott-Aldrich syndrome protein family member 1(WASF1) - CSB-YP852883HU CSB-EP852883HU CSB-BP852883HU CSB-MP852883HU from Cusabio
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WAVE1 (N-terminal region) - WX1735 from ECM Biosciences
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Wiskott-Aldrich syndrome protein family member 1 (WASF1) , Recombinant Protein - MBS1306872 from MyBioSource
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WASF1/WAVE, Peptide - MBS427886 from MyBioSource
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WAVE1 (N-terminal region) Peptide, Peptide - MBS474070 from MyBioSource
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WASF1/WAVE1 Recombinant Protein Antigen - NBP1-83018PEP from Novus Biologicals
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WASF1 (pY125) Blocking Peptide - abx061193 from Abbexa
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WASF1 Blocking Peptide - abx162076 from Abbexa
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WASF1 Peptide, Human - M34GP17377H from Creative Peptides
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WASF1 Blocking Peptide - CBP4865 from Cohesion Biosciences
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WASF1 (pY125) Blocking Peptide - CBP5106 from Cohesion Biosciences
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