| Gene Symbol |
SOX3
|
| Entrez Gene |
6658
|
| Alt Symbol |
GHDX, MRGH, PHP, PHPX, SOXB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SRY (sex determining region Y)-box 3
|
| Other Description |
transcription factor SOX-3
|
| Swissprots |
Q9NP49 P35714 Q5JWI3 P41225
|
| Accessions |
AAF73059 CAA50465 EAW88422 P41225 AK313820 BC093863 AAH93863 BC093865 AAH93865 X65665 CAA46616 X71137 CAA50467 NM_005634 NP_005625
|
| Function |
Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
![Western Blot: SOX3 Overexpression Lysate (Adult Normal) [NBP2-07720] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SOX3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9122_SOX3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07720-img0001.jpg)