Gene Symbol | SOX3 |
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Entrez Gene | 6658 |
Alt Symbol | GHDX, MRGH, PHP, PHPX, SOXB |
Species | Human |
Gene Type | protein-coding |
Description | SRY (sex determining region Y)-box 3 |
Other Description | transcription factor SOX-3 |
Swissprots | Q9NP49 P35714 Q5JWI3 P41225 |
Accessions | AAF73059 CAA50465 EAW88422 P41225 AK313820 BC093863 AAH93863 BC093865 AAH93865 X65665 CAA46616 X71137 CAA50467 NM_005634 NP_005625 |
Function | Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus. |
Sox-3 CRISPR/Cas9 KO Plasmid (h) - sc-403896 from Santa Cruz Biotechnology
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Sox-3 HDR Plasmid (h) - sc-403896-HDR from Santa Cruz Biotechnology
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Sox-3 Double Nickase Plasmid (h) - sc-403896-NIC from Santa Cruz Biotechnology
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Sox-3 Double Nickase Plasmid (h2) - sc-403896-NIC-2 from Santa Cruz Biotechnology
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Sox-3 CRISPR Activation Plasmid (h) - sc-403896-ACT from Santa Cruz Biotechnology
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Sox-3 CRISPR Activation Plasmid (h2) - sc-403896-ACT-2 from Santa Cruz Biotechnology
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Sox-3 Lentiviral Activation Particles (h) - sc-403896-LAC from Santa Cruz Biotechnology
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Sox-3 Lentiviral Activation Particles (h2) - sc-403896-LAC-2 from Santa Cruz Biotechnology
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Sox-3 siRNA (h) - sc-38410 from Santa Cruz Biotechnology
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Sox-3 shRNA Plasmid (h) - sc-38410-SH from Santa Cruz Biotechnology
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Sox-3 shRNA (h) Lentiviral Particles - sc-38410-V from Santa Cruz Biotechnology
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SOX3 RNAi - H00006658-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN20357 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20357 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06323 from Sigma-Aldrich
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SOX3 siRNA (Human) - CRH4538 from Cohesion Biosciences
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SOX3 - MBS8213631 from MyBioSource
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shRNA set against Human SOX3 (NM_005634.2) - SHH415420 from Creative biogene
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shRNA set against Human SOX3(NM_005634.2) - SHL017432 from Creative biogene
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SOX3 shRNA Plasmid (Human) - CHH4538 from Cohesion Biosciences
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SOX3 miRNA 3'UTR clone - MiUTR1H-09767 from Creative biogene
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