Gene Symbol | CATSPER3 |
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Entrez Gene | 347732 |
Alt Symbol | CACRC |
Species | Human |
Gene Type | protein-coding |
Description | cation channel, sperm associated 3 |
Other Description | ca(v)-like protein|calcium channel repeat containing 1|cation channel sperm-associated protein 3|one-repeat calcium channel-like protein|putative ion channel CatSper3 |
Swissprots | Q86XS6 Q86XQ3 |
Accessions | EAW62228 Q86XQ3 AF432876 AAO85416 AK292427 BAF85116 AW008956 AY156951 AAO13012 BC101692 AAI01693 BC110384 AAI10385 BI827754 BN000272 CAE30476 NM_178019 NP_821138 |
Function | Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}. |
Subcellular Location | Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail. |
Tissue Specificity | Testis-specific. {ECO:0000269|PubMed:12646162, ECO:0000269|PubMed:12932298, ECO:0000269|PubMed:17347248}. |
CatSper3 (H-216) - sc-98702 from Santa Cruz Biotechnology
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CatSper3 (V-14) - sc-82800 from Santa Cruz Biotechnology
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Anti-CATSPER3 antibody - ab197924 from Abcam
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Anti-CATSPER3 antibody - C-terminal - ab171544 from Abcam
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CATSPER3 Antibody - NBP1-46507 from Novus Biologicals
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CATSPER3 Antibody - H00347732-A01 from Novus Biologicals
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CATSPER3 Polyclonal Antibody - bs-7136R from Bioss
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Anti-CATSPER3 antibody produced in rabbit - SAB4301159 from Sigma-Aldrich
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CATSPER antibody - orb101304 from Biorbyt
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CATSPER3 antibody - H00347732-A01 from Acris Antibodies
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CATSPER3 Antibody - 36315 from Signalway Antibody
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CATSPER3, Polyclonal Antibody - MBS2526279 from MyBioSource
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CATSPER3, Polyclonal Antibody - MBS2516437 from MyBioSource
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CATSPER3 Polyclonal Antibody - ESAP11201 from Elabscience
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CATSPER3 Polyclonal Antibody - ESAP15129 from Elabscience
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Anti-CATSPER3 (aa 299-398) polyclonal antibody - DPAB-DC1677 from Creative Diagnostics
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Anti-CATSPER3 (aa 368-398) polyclonal antibody - DPABH-09227 from Creative Diagnostics
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CATSPER3 Antibody - CSB-PA091642 from Cusabio
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CATSPER3 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-7136R-A350 from Bioss
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CATSPER3 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-7136R-A488 from Bioss
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CATSPER3 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-7136R-A555 from Bioss
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CATSPER3 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-7136R-A647 from Bioss
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CATSPER3 Polyclonal Antibody, Cy3 Conjugated - bs-7136R-Cy3 from Bioss
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CATSPER3 Polyclonal Antibody, Cy5 Conjugated - bs-7136R-Cy5 from Bioss
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CATSPER3 Polyclonal Antibody, Cy5.5 Conjugated - bs-7136R-Cy5.5 from Bioss
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