CATSPER3

Gene Symbol CATSPER3
Entrez Gene 347732
Alt Symbol CACRC
Species Human
Gene Type protein-coding
Description cation channel, sperm associated 3
Other Description ca(v)-like protein|calcium channel repeat containing 1|cation channel sperm-associated protein 3|one-repeat calcium channel-like protein|putative ion channel CatSper3
Swissprots Q86XS6 Q86XQ3
Accessions EAW62228 Q86XQ3 AF432876 AAO85416 AK292427 BAF85116 AW008956 AY156951 AAO13012 BC101692 AAI01693 BC110384 AAI10385 BI827754 BN000272 CAE30476 NM_178019 NP_821138
Function Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
Subcellular Location Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
Tissue Specificity Testis-specific. {ECO:0000269|PubMed:12646162, ECO:0000269|PubMed:12932298, ECO:0000269|PubMed:17347248}.

Human CATSPER3 protein fragment - ab166329 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab166329 on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human CATSPER3 Protein - H00347732-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

CTSR3-Antibody-C-term-Blocking-peptide - BP13012b from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

CATSPER3 - H00347732-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Source in vitro transl.
Species Human

CATSPER3 - H00347732-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Source in vitro transl.
Species Human

CATSPER3 fusion protein - Ag15380 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PGEX-4T
Species Human

CATSPER3 fusion protein - Ag16914 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human CATSPER3, His-tagged - CATSPER3-10747H from Creative Biomart

Category Protein
Source E.coli
Species Human

CATSPER3 Peptide, Human - M34GP02411H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Cation channel sperm-associated protein 3 (CATSPER3), Recombinant Protein - MBS7010771 from MyBioSource

Category Protein
Prices $1,205.00, $2,190.00, $3,395.00
Sizes 10 µg, 50 µg, 100 µg
Source Cell Free Expression
Species Human
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