| Gene Symbol |
CATSPER3
|
| Entrez Gene |
347732
|
| Alt Symbol |
CACRC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cation channel, sperm associated 3
|
| Other Description |
ca(v)-like protein|calcium channel repeat containing 1|cation channel sperm-associated protein 3|one-repeat calcium channel-like protein|putative ion channel CatSper3
|
| Swissprots |
Q86XS6 Q86XQ3
|
| Accessions |
EAW62228 Q86XQ3 AF432876 AAO85416 AK292427 BAF85116 AW008956 AY156951 AAO13012 BC101692 AAI01693 BC110384 AAI10385 BI827754 BN000272 CAE30476 NM_178019 NP_821138
|
| Function |
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers. Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
|
| Subcellular Location |
Cell projection, cilium, flagellum membrane; Multi-pass membrane protein. Note=Specifically located in the principal piece of sperm tail.
|
| Tissue Specificity |
Testis-specific. {ECO:0000269|PubMed:12646162, ECO:0000269|PubMed:12932298, ECO:0000269|PubMed:17347248}.
|